Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/44933
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dc.contributor.authorGuy, John
dc.contributor.authorShaw, Gerry
dc.contributor.authorRoss-Cisneros, Fred N.
dc.contributor.authorQuiros, Peter
dc.contributor.authorSalomão, Solange Rios [UNIFESP]
dc.contributor.authorBerezovsky, Adriana [UNIFESP]
dc.contributor.authorCarelli, Valerio
dc.contributor.authorFeuer, William J.
dc.contributor.authorSadun, Alfredo Arrigo
dc.date.accessioned2018-06-18T11:04:10Z-
dc.date.available2018-06-18T11:04:10Z-
dc.date.issued2008-12-22
dc.identifierhttp://www.molvis.org/molvis/v14/a281/
dc.identifier.citationMolecular Vision. Atlanta: Molecular Vision, v. 14, n. 281, p. 2443-2450, 2008.
dc.identifier.issn1090-0535
dc.identifier.urihttp://repositorio.unifesp.br/11600/44933-
dc.description.abstractPurpose: To determine the profile of neurodegeneration in Leber hereditary optic neuropathy (LHON).Methods: We quantitated serum levels of phosphorylated neurofilament heavy chain (pNF-H) in a Brazilian pedigree of 16 affected patients and 59 carriers with LHON, both molecularly characterized as harboring the G to A mutation at nucleotide 11,778 of the mitochondrial genome. The association of subject characteristics to pNF-H levels was studied with multiple regression; pNF-H data were square-root transformed to effect normality of distribution of residuals. Relationships between the square-root of pNF-H and age and sex were investigated within groups with Pearson correlation and the two-sample t-test. Linear regression was used to assess the difference between groups and to determine if the relationship of age was different between affected individuals and carriers. Results of plotting pNF-H levels by age suggested a nonlinear, quadratic association so age squared was used in the statistical analysis. ANCOVA was used to assess the influence of age and group on pNF-H levels.Results: In the carrier group, there was a significant correlation of square-root pNF-H (mean=0.24 ng/ml(2)) with age (r=0.30, p=0.022) and a stronger correlation with quadratic age (r=0.37, p=0.003). With a higher mean pNF-H (0.33 ng/ml2) for the affected group, correlations were of similar magnitude, although they were not statistically significant: age (r=0.22, p=0.42), quadratic age (r=0.22, p=0.45). There was no correlation between age and pNF-H levels (mean=0.34 ng/ml(2)) in the off-pedigree group: age (r=0.03, p=0.87), quadratic age (r=0.04, p=0.84). There was no difference between sexes and pNF-H levels in any of the groups ( affected, p=0.65; carriers, p=0.19; off-pedigree, p=0.93).Conclusions: Elevated pNF-H released into the serum of some affected LHON patients may suggest that axonal degeneration occurs at some point after loss of visual function. Increases in pNF-H levels of carriers with increasing age, not seen in off-pedigree controls, may suggest subtle subclinical optic nerve degeneration.en
dc.format.extent2443-2450
dc.language.isoeng
dc.publisherMolecular Vision
dc.relation.ispartofMolecular Vision
dc.rightsAcesso aberto
dc.titlePhosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)en
dc.typeArtigo
dc.contributor.institutionBascom Palmer Eye Inst
dc.contributor.institutionUniv Miami
dc.contributor.institutionUniv Florida
dc.contributor.institutionDoheny Eye Inst
dc.contributor.institutionKeck USC Sch Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Bologna
dc.description.affiliationBascom Palmer Eye Inst, McKnight Vis Res Ctr, Miami, FL 33136 USA
dc.description.affiliationUniv Miami, Miller Sch Med, Dept Ophthalmol, Miami, FL 33136 USA
dc.description.affiliationUniv Florida, Dept Neurosci, McKnight Brain Inst, Coll Med, Gainesville, FL 32610 USA
dc.description.affiliationDoheny Eye Inst, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliationKeck USC Sch Med, Los Angeles, CA USA
dc.description.affiliationDoheny Eye Inst, Dept Neurosurg, Los Angeles, CA 90033 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUniv Bologna, Dipartimento Sci Neurol, Bologna, Italy
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sponsorshipIDEY018600-01
dc.description.sponsorshipID1R01EY017141-01A2
dc.description.sponsorshipIDEY014801
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000263857200001
Appears in Collections:Artigo

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