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Title: COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
Authors: Sampaio, Aline Santos
Hounie, Ana Gabriela
Petribu, Katia
Cappi, Carolina
Morais, Ivanil
Vallada, Homero
Rosario, Maria Conceição do [UNIFESP]
Stewart, S. Evelyn
Fargeness, Jesen
Mathews, Carol
Arnold, Paul
Hanna, Gregory L.
Richter, Margaret
Kennedy, James
Fontenelle, Leonardo
Braganca Pereira, Carlos Alberto de
Pauls, David L.
Miguel, Euripedes Constantino
Universidade de São Paulo (USP)
Universidade Federal da Bahia (UFBA)
Univ Pernambuco
Universidade Federal de São Paulo (UNIFESP)
British Columbia Mental Hlth & Addict Res Inst
Massachusetts Gen Hosp
Univ Calif San Francisco
Hosp Sick Children
Univ Michigan
Sunnybrook Hlth Sci Ctr
Univ Toronto
Universidade Federal do Rio de Janeiro (UFRJ)
Issue Date: 20-Mar-2015
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 10, n. 3, 14 p., 2015.
Abstract: ObjectiveObsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. the catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. in an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design.MethodsTransmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed.ResultsOCD, broad and narrow phenotypes, were not associated with any of the investigated COMT and MAO-A polymorphisms. in addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A.ConclusionsThe findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. the evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders.
ISSN: 1932-6203
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