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|Title:||Neurocysticercosis: A natural human model of epileptogenesis|
|Authors:||Nash, Theodore E.|
Loeb, Jeffrey A.
Theodore, William H.
Sander, Josemir W.
Cavalheiro, Esper [UNIFESP]
Del Brutto, Oscar H.
Takayanagui, Osvaldo M.
Pretell, E. Javier
White, A. Clinton
Gonzales, Armando E.
Gilman, Robert H.
Garcia, Hector H.
Natl Inst Allergy & Infect Dis
Natl Inst Neurol Disorders & Stroke
Ben Gurion Univ Negev
UCL Inst Neurol
Universidade Federal de São Paulo (UNIFESP)
Univ Espiritu Santo
Universidade de São Paulo (USP)
Natl Autonomous Univ Mexico & Natl Inst Neurol &
Univ Peruana Cayetano Heredia
US Naval Med Res Unit 6
Hosp Alberto Sabogal
Natl Univ San Marcos
Johns Hopkins Bloomberg Sch Publ Hlth
Inst Neurol Dis
|Citation:||Epilepsia. Hoboken: Wiley-Blackwell, v. 56, n. 2, p. 177-183, 2015.|
|Abstract:||ObjectiveTo develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis.MethodsA workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.ResultsHuman neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.SignificanceNaturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.|
|Appears in Collections:||Em verificação - Geral|
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