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Title: Neurocysticercosis: A natural human model of epileptogenesis
Authors: Nash, Theodore E.
Mahanty, Siddhartha
Loeb, Jeffrey A.
Theodore, William H.
Friedman, Alon
Sander, Josemir W.
Singh, Gagandeep
Cavalheiro, Esper [UNIFESP]
Del Brutto, Oscar H.
Takayanagui, Osvaldo M.
Fleury, Agnes
Verastegui, Manuela
Preux, Pierre-Marie
Montano, Silvia
Pretell, E. Javier
White, A. Clinton
Gonzales, Armando E.
Gilman, Robert H.
Garcia, Hector H.
Natl Inst Allergy & Infect Dis
Univ Illinois
Natl Inst Neurol Disorders & Stroke
Ben Gurion Univ Negev
Dalhousie Univ
UCL Inst Neurol
Netherlands Fdn
Dept Neurol
Universidade Federal de São Paulo (UNIFESP)
Univ Espiritu Santo
Universidade de São Paulo (USP)
Natl Autonomous Univ Mexico & Natl Inst Neurol &
Univ Peruana Cayetano Heredia
Univ Limoges
US Naval Med Res Unit 6
Hosp Alberto Sabogal
Univ Texas
Natl Univ San Marcos
Johns Hopkins Bloomberg Sch Publ Hlth
Inst Neurol Dis
Keywords: Epilepsy
Taenia solium
Issue Date: 1-Feb-2015
Publisher: Wiley-Blackwell
Citation: Epilepsia. Hoboken: Wiley-Blackwell, v. 56, n. 2, p. 177-183, 2015.
Abstract: ObjectiveTo develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis.MethodsA workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.ResultsHuman neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.SignificanceNaturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.
ISSN: 0013-9580
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