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Title: Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors-data from a multi-ethnic Latin American cohort
Authors: Garcia, Mercedes A.
Alarcon, Graciela S.
Boggio, Gabriela
Hachuel, Leticia
Ines Marcos, Ana
Carlos Marcos, Juan
Gentiletti, Silvana
Caeiro, Francisco
Sato, Emilia Inoue [UNIFESP]
Borba, Eduardo F.
Tavares Brenol, Joao C.
Massardo, Loreto
Fernando Molina-Restrepo, Jose
Vasquez, Gloria
Guibert-Toledano, Marlene
Barile-Fabris, Leonor
Amigo, Mary-Carmen
Huerta-Yanez, Guillermo F.
Cucho-Venegas, Jorge M.
Chacon-Diaz, Rosa
Pons-Estel, Bernardo A.
Grp Latino Amer Estudio Lupus
Hosp Interzonal Gen Agudos Gen San Martin
Univ Alabama Birmingham
Univ Nacl Rosario
Hosp Prov Rosario
Hosp Privado
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Fed Rio Grande do Sul
Pontificia Univ Catolica Chile
Univ CES
Univ Antioquia
Ctr Invest Med Quirurg
Hosp Especialidades Ctr Med Nacl Siglo XXI
Ctr Med ABC
Hosp Miguel Hidalgo
Hosp Nacl Guillermo Almenara Irigoyen EsSalud
Hosp Univ Caracas
Keywords: systemic lupus erythematosus
cardiac disease
Issue Date: 1-Aug-2014
Publisher: Oxford Univ Press
Citation: Rheumatology. Oxford: Oxford Univ Press, v. 53, n. 8, p. 1431-1438, 2014.
Abstract: Objectives. the aim of this study was to assess the cumulative incidence, risk and protective factors and impact on mortality of primary cardiac disease in SLE patients (disease duration <= 2 years) from a multi-ethnic, international, longitudinal inception cohort (34 centres, 9 Latin American countries).Methods. Risk and protective factors of primary cardiac disease (pericarditis, myocarditis, endocarditis, arrhythmias and/or valvular abnormalities) were evaluated.Results. of 1437 patients, 202 (14.1%) developed one or more manifestations: 164 pericarditis, 35 valvulopathy, 23 arrhythmias, 7 myocarditis and 1 endocarditis at follow-up; 77 of these patients also had an episode of primary cardiac disease at or before recruitment. in the multivariable parsimonious model, African/Latin American ethnicity [odds ratio (OR) 1.80, 95% CI 1.13, 2.86], primary cardiac disease at or before recruitment (OR 6.56, 95% CI 4.56, 9.43) and first SLICC/ACR Damage Index for SLE assessment (OR 1.31, 95% CI 1.14, 1.50) were risk factors for the subsequent occurrence of primary cardiac disease. CNS involvement (OR 0.44, 95% CI 0.25, 0.75) and antimalarial treatment (OR 0.62, 95% CI 0.44, 0.89) at or before recruitment were negatively associated with the occurrence of primary cardiac disease risk. Primary cardiac disease was not independently associated with mortality.Conclusion. Primary cardiac disease occurred in 14.1% of SLE patients of the Grupo Latino Americano de Estudio de Lupus cohort and pericarditis was its most frequent manifestation. African origin and lupus damage were found to be risk factors, while CNS involvement at or before recruitment and antimalarial treatment were protective. Primary cardiac disease had no impact on mortality.
ISSN: 1462-0324
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