Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/37689
Title: Strategies to manage hepatitis C virus (HCV) disease burden
Authors: Wedemeyer, H.
Duberg, A. S.
Buti, M.
Rosenberg, W. M.
Frankova, S.
Esmat, G.
Ormeci, N.
Van Vlierberghe, H.
Gschwantler, M.
Akarca, U.
Aleman, S.
Balik, I.
Berg, T.
Bihl, F.
Bilodeau, M.
Blasco, A. J.
Brandao Mello, C. E.
Bruggmann, P.
Calinas, F.
Calleja, J. L.
Cheinquer, H.
Christensen, P. B.
Clausen, M.
Coelho, H. S. M.
Cornberg, M.
Cramp, M. E.
Dore, G. J.
Doss, W.
El-Sayed, M. H.
Ergor, G.
Estes, C.
Falconer, K.
Felix, J.
Ferraz, Maria Lucia Gomes [UNIFESP]
Ferreira, Paulo Roberto [UNIFESP]
Garcia-Samaniego, J.
Gerstoft, J.
Giria, J. A.
Goncales, F. L.
Guimaraes Pessoa, M.
Hezode, C.
Hindman, S. J.
Hofer, H.
Husa, P.
Idilman, R.
Kaberg, M.
Kaita, K. D. E.
Kautz, A.
Kaymakoglu, S.
Krajden, M.
Krarup, H.
Laleman, W.
Lavanchy, D.
Lazaro, P.
Marinho, R. T.
Marotta, P.
Mauss, S.
Mendes Correa, M. C.
Moreno, C.
Muellhaupt, B.
Myers, R. P.
Nemecek, V.
Ovrehus, A. L. H.
Parkes, J.
Peltekian, K. M.
Ramji, A.
Razavi, H.
Reis, N.
Roberts, S. K.
Roudot-Thoraval, F.
Ryder, S. D.
Sarmento-Castro, R.
Sarrazin, C.
Semela, D.
Sherman, M.
Shiha, G. E.
Sperl, J.
Starkel, P.
Stauber, R. E.
Thompson, A. J.
Urbanek, P.
Van Damme, P.
van Thiel, I.
Vandijck, D.
Vogel, W.
Waked, I.
Weis, N.
Wiegand, J.
Yosry, A.
Zekry, A.
Negro, F.
Sievert, W.
Gower, E.
Hannover Med Sch
German Liver Fdn
Orebro Univ Hosp
Univ Orebro
Hosp Valle de Hebron
UCL
Inst Clin & Expt Med
Cairo Univ
Ankara Univ
Ghent Univ Hosp
Wilhelminenspital Stadt Wien
Ege Univ
Karolinska Inst
Karolinska Univ Hosp
Univ Leipzig
Osped Cantonale
Univ Montreal
Adv Tech Hlth Serv Res TAISS
Fed Univ State Rio de Janeiro
Arud Ctr Addict Med
Hosp Santo Antonio Capuchos
Hosp Puerta Hierro
Univ Fed Rio Grande do Sul
Odense Univ Hosp
Region Hosp Hovedstaden
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Plymouth
Univ New S Wales
Ain Shams Univ
Dokuz Eylul Univ
Ctr Dis Anal CDA
Exigo Consultores
Universidade Federal de São Paulo (UNIFESP)
Hosp Carlos III
Univ Copenhagen
Direccao Geral Saude
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Hop Henri Mondor
Med Univ Vienna
Masaryk Univ
Univ Manitoba
Hlth Sci Ctr
European Liver Patients Assoc
Istanbul Univ
Univ British Columbia
Aalborg Univ Hosp
Katholieke Univ Leuven
Univ Western Ontario
Univ Dusseldorf
Univ Libre Brussels
Univ Zurich Hosp
Univ Calgary
Natl Inst Publ Hlth
Univ Southhampton
Dalhousie Univ & Hepatol Serv
Assembleia Republ
Alfred Hosp
Monash Univ
Nottingham Univ Hosp NHS Trust
Biomed Res Unit
Ctr Hosp Porto
JW Goethe Univ Hosp
Cantonal Hosp St Gallen
Univ Toronto
Egyptian Liver Res Inst & Hosp ELRIAH
Catholic Univ Louvain
Med Univ Graz
St Vincents Hosp
Univ Melbourne
Charles Univ Prague
Cent Mil Hosp
Univ Antwerp
Deutsch Leberhilfe eV
Univ Ghent
Hasselt Univ
Med Univ Innsbruck
Natl Liver Inst
Copenhagen Univ Hosp
Univ Hosp
Monash Hlth
Keywords: diagnosis
epidemiology
HCV
mortality
treatment
scenarios
prevalence
incidence
hepatitis C
disease burden
Issue Date: 1-May-2014
Publisher: Wiley-Blackwell
Citation: Journal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 60-89, 2014.
Abstract: The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. the largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
URI: http://repositorio.unifesp.br/handle/11600/37689
ISSN: 1352-0504
Other Identifiers: http://dx.doi.org/10.1111/jvh.12249
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