Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/37688
Title: The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Authors: Razavi, H.
Waked, I.
Sarrazin, C.
Myers, R. P.
Idilman, R.
Calinas, F.
Vogel, W.
Mendes Correa, M. C.
Hezode, C.
Lazaro, P.
Akarca, U.
Aleman, S.
Balik, I.
Berg, T.
Bihl, F.
Bilodeau, M.
Blasco, A. J.
Brandao Mello, C. E.
Bruggmann, P.
Buti, M.
Calleja, J. L.
Cheinquer, H.
Christensen, P. B.
Clausen, M.
Coelho, H. S. M.
Cramp, M. E.
Dore, G. J.
Doss, W.
Duberg, A. S.
El-Sayed, M. H.
Ergor, G.
Esmat, G.
Falconer, K.
Felix, J.
Ferraz, Maria Lucia Gomes [UNIFESP]
Ferreira, Paulo Roberto [UNIFESP]
Frankova, S.
Garcia-Samaniego, J.
Gerstoft, J.
Giria, J. A.
Goncales, F. L.
Gower, E.
Gschwantler, M.
Guimaraes Pessoa, M.
Hindman, S. J.
Hofer, H.
Husa, P.
Kaberg, M.
Kaita, K. D. E.
Kautz, A.
Kaymakoglu, S.
Krajden, M.
Krarup, H.
Laleman, W.
Lavanchy, D.
Marinho, R. T.
Marotta, P.
Mauss, S.
Moreno, C.
Murphy, K.
Negro, F.
Nemecek, V.
Ormeci, N.
Ovrehus, A. L. H.
Parkes, J.
Pasini, K.
Peltekian, K. M.
Ramji, A.
Reis, N.
Roberts, S. K.
Rosenberg, W. M.
Roudot-Thoraval, F.
Ryder, S. D.
Sarmento-Castro, R.
Semela, D.
Sherman, M.
Shiha, G. E.
Sievert, W.
Sperl, J.
Starkel, P.
Stauber, R. E.
Thompson, A. J.
Urbanek, P.
Van Damme, P.
van Thiel, I.
Van Vlierberghe, H.
Vandijck, D.
Wedemeyer, H.
Weis, N.
Wiegand, J.
Yosry, A.
Zekry, A.
Cornberg, M.
Muellhaupt, B.
Estes, C.
Ctr Dis Anal
Natl Liver Inst
JW Goethe Univ Hosp
Univ Calgary
Ankara Univ
Hosp Santo Antonio Capuchos
Med Univ Innsbruck
Universidade de São Paulo (USP)
Hop Henri Mondor
Adv Tech Hlth Serv Res TAISS
Ege Univ
Karolinska Inst
Karolinska Univ Hosp
Univ Leipzig
Osped Cantonale
Univ Montreal
Fed Univ State Rio de Janeiro
Arud Ctr Addict Med
Hosp Valle de Hebron
Hosp Puerta Hierro
Univ Fed Rio Grande do Sul
Odense Univ Hosp
Reg Hosp Hovedstaden
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Plymouth
Univ New S Wales
Cairo Univ
Orebro Univ Hosp
Univ Orebro
Ain Shams Univ
Dokuz Eylul Univ
Exigo Consultores
Universidade Federal de São Paulo (UNIFESP)
Inst Clin & Expt Med
Hosp Carlos III
Univ Copenhagen
Direccao Geral Saude
Universidade Estadual de Campinas (UNICAMP)
Wilhelminenspital Stadt Wien
Med Univ Vienna
Masaryk Univ
Univ Manitoba
Hlth Sci Ctr
European Liver Patients Assoc
Istanbul Univ
Univ British Columbia
Aalborg Univ Hosp
Katholieke Univ Leuven
Hosp Santa Maria
Univ Western Ontario
Univ Dusseldorf
Univ Libre Brussels
Univ Hosp
Natl Inst Publ Hlth
Univ Southhampton
Dalhousie Univ & Hepatol Serv
Assembleia Republ
Alfred Hosp
Monash Univ
UCL
Nottingham Univ Hosp NHS Trust
Biomed Res Unit
Ctr Hosp Porto
Cantonal Hosp St Gallen
Univ Toronto
Egyptian Liver Res Inst & Hosp
Monash Hlth
Catholic Univ Louvain
Med Univ Graz
St Vincents Hosp
Univ Melbourne
Charles Univ Prague
Cent Mil Hosp
Univ Antwerp
Deutsch Leberhilfe eV
Ghent Univ Hosp
Univ Ghent
Hannover Med Sch
Copenhagen Univ Hosp
Univ Zurich Hosp
Keywords: HCV
diagnosis
treatment
hepatitis C
prevalence
epidemiology
disease burden
mortality
incidence
Issue Date: 1-May-2014
Publisher: Wiley-Blackwell
Citation: Journal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 34-59, 2014.
Abstract: The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. in addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.
URI: http://repositorio.unifesp.br/handle/11600/37688
ISSN: 1352-0504
Other Identifiers: http://dx.doi.org/10.1111/jvh.12248
Appears in Collections:Em verificação - Geral

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