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Title: Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative
Authors: Sivera, Francisca
Andres, Mariano
Carmona, Loreto
Kydd, Alison S. R.
Moi, John
Seth, Rakhi
Sriranganathan, Melonie
van Durme, Caroline
van Echteld, Irene
Vinik, Ophir
Wechalekar, Mihir D.
Aletaha, Daniel
Bombardier, Claire
Buchbinder, Rachelle
Edwards, Christopher J.
Landewe, Robert B.
Bijlsma, Johannes W.
Branco, Jaime C.
Burgos-Vargas, Ruben
Catrina, Anca I.
Elewaut, Dirk
Ferrari, Antonio J. L. [UNIFESP]
Kiely, Patrick
Leeb, Burkhard F.
Montecucco, Carlomaurizio
Mueller-Ladner, Ulf
Ostergaard, Mikkel
Zochling, Jane
Falzon, Louise
van der Heijde, Desiree M.
Hosp Gen Univ Elda
Hosp Gen Univ Alicante
Univ Camilo Jose Cela
Univ British Columbia
Royal Melbourne Hosp
Univ Hosp Southampton NHS Fdn Trust
NIHR Wellcome Trust Clin Res Facil
Ctr Hosp Univ Liege
Maastricht Univ
Atrium Med Ctr
Univ Toronto
Repatriat Gen Hosp
Flinders Univ S Australia
Med Univ Vienna
Mt Sinai Hosp
Cabrini Hosp
Monash Univ
Univ Amsterdam
Univ Med Ctr Utrecht
Univ Nova Lisboa
EPE Hosp Egas Moniz
Hosp Gen Mexico City
Karolinska Univ Hosp
Karolinska Inst
Ghent Univ Hosp
Universidade Federal de São Paulo (UNIFESP)
St Georges Healthcare NHS Trust
State Hosp Stockerau
Univ Pavia
Univ Giessen
Copenhagen Univ Hosp
Menzies Res Inst Tasmania
Columbia Univ
Leiden Univ
Issue Date: 1-Feb-2014
Publisher: Bmj Publishing Group
Citation: Annals of the Rheumatic Diseases. London: Bmj Publishing Group, v. 73, n. 2, p. 328-335, 2014.
Abstract: We aimed to develop evidence-based multinational recommendations for the diagnosis and management of gout. Using a formal voting process, a panel of 78 international rheumatologists developed 10 key clinical questions pertinent to the diagnosis and management of gout. Each question was investigated with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010-2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level of evidence. Agreement and potential impact on clinical practice were assessed. Combining evidence and clinical expertise, 10 recommendations were produced. One recommendation referred to the diagnosis of gout, two referred to cardiovascular and renal comorbidities, six focused on different aspects of the management of gout (including drug treatment and monitoring), and the last recommendation referred to the management of asymptomatic hyperuricaemia. the level of agreement with the recommendations ranged from 8.1 to 9.2 (mean 8.7) on a 1-10 scale, with 10 representing full agreement. Ten recommendations on the diagnosis and management of gout were established. They are evidence-based and supported by a large panel of rheumatologists from 14 countries, enhancing their utility in clinical practice.
ISSN: 0003-4967
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