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Title: Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet
Authors: Azzalis, Ligia A.
Fonseca, Fernando L. A.
Simon, Karin A.
Schindler, Fernanda
Giavarotti, Leandro
Monteiro, Hugo P. [UNIFESP]
Videla, Luis A.
Junqueira, Virginia B. C.
Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
Univ Anhembi Morumbi
Univ Chile
Keywords: Cytochrome P4502E1
standard diet
oxidative stress
rat liver
Issue Date: 1-Jul-2012
Publisher: Informa Healthcare
Citation: Drug and Chemical Toxicology. London: Informa Healthcare, v. 35, n. 3, p. 324-329, 2012.
Abstract: Expression of cytochrome P4502E1 (CYP2E1) is very much influenced by nutritional factors, especially carbohydrate consumption, and various results concerning the expression of CYP2E1 were obtained with a low-carbohydrate diet. This study describes the effects of ethanol treatment on CYP2E1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. Rats were fed for 1, 2, 3, or 4 weeks a commercial diet plus an ethanol-sucrose solution. the results have shown that ethanol administration was associated with CYP2E1 induction and stabilization without related oxidative stress. Our findings suggest that experimental models with a low-carbohydrate/high-fat diet produce some undesirable CYP2E1 changes that are not present when a balanced standard diet is given.
ISSN: 0148-0545
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