Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33727
Title: CENTRAL N-ACETYLCYSTEINE EFFECTS ON BAROREFLEX in JUVENILE SPONTANEOUSLY HYPERTENSIVE RATS
Authors: Valenti, Vitor E. [UNIFESP]
De Abreu, Luiz Carlos
Sato, Monica A.
Saldiva, Paulo H. N.
Fonseca, Fernando L. A.
Giannocco, Gisele
Riera, Andreas R. P.
Ferreira, Celso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Baroreflex
acetylcysteine
rats
inbred SHR
oxidative stress
Issue Date: 1-Jun-2011
Publisher: Imperial College Press
Citation: Journal of Integrative Neuroscience. London: Imperial College Press, v. 10, n. 2, p. 161-176, 2011.
Abstract: In this study, we evaluated the acute effects of central NAC administration on baroreflex in juvenile SHR and Wistar Kyoto (WKY) rats. Male SHR and WKY rats (8 10 weeks old) were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4th V). the femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. After basal MAP and HR recordings, the baroreflex was tested with a pressor dose of phenylephrine (PHE, 8 mu g/kg, bolus) and a depressor dose of sodium nitroprusside (SNP, 50 mu g/kg, bolus). Baroreflex was evaluated before, 5, 15, 30 and 60 minutes after NAC injection into the 4th V. Vehicle treatment did not change baroreflex responses in WKY and SHR. Central NAC slightly but significantly increased basal HR at 15 minutes and significantly reduced PHE-induced increase in MAP 30 and 60 minutes after NAC injection (p < 0.05) in WKY rats. in relation to SHR, NAC decreased HR range 15 and 30 minutes after its administration. in conclusion, acute NAC into the 4th V does not improve baroreflex in juvenile SHR.
URI: http://repositorio.unifesp.br/handle/11600/33727
ISSN: 0219-6352
Other Identifiers: http://dx.doi.org/10.1142/S0219635211002671
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.