Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33491
Title: CATALASE INHIBITION INTO the FOURTH CEREBRAL VENTRICLE AFFECTS BRADYCARDIC PARASYMPATHETIC RESPONSE TO INCREASE in ARTERIAL PRESSURE WITHOUT CHANGING the BAROREFLEX
Authors: Valenti, Vitor E. [UNIFESP]
De Abreu, Luiz Carlos
Sato, Monica A.
Fonseca, Fernando L. A.
Perez Riera, Andres R.
Ferreira, Celso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
Keywords: Baroreflex
oxidative stress
catalase
medulla oblongata
cardiovascular system
reflex
Issue Date: 1-Mar-2011
Publisher: Imperial College Press
Citation: Journal of Integrative Neuroscience. London: Imperial College Press, v. 10, n. 1, p. 1-14, 2011.
Abstract: Exogenous catalase influences neural control of cardiovascular system; however, we do not know yet if its inhibition into the fourth cerebral ventricle (4(th) V) influences baroreflex regulation. We evaluated the effects of central catalase inhibition on baroreflex in conscious Wistar rats. We used males Wistar rats (320-370 g), which were implanted with a stainless steel guide cannula into 4(th) V. the femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. After basal MAP and HR recordings, the baroreflex was tested with a pressor dose of phenylephrine (PHE, 8 mu g/kg, bolus) and a depressor dose of sodium nitroprusside (SNP, 50 mu g/kg, bolus). Baroreflex was evaluated before 5, 15, 30 and 60 minutes after 3-amino1,2,4- triazole (ATZ, 0.001 g/100 mu L) injection into the 4(th) V. Vehicle treatment did not change baroreflex responses. ATZ attenuated bradycardic peak and reduced HR range at 30 minutes. ATZ into the 4(th) V reduced bradycardic and tachycardic reflex responses to increase and decrease MAP, respectively (p < 0.05) 30 minutes after its microinjection without significantly changing the basal MAP and HR. in conclusion, central catalase inhibition influenced the highest parasympathetic response to MAP increase in conscious Wistar rats without change baroreflex gain.
URI: http://repositorio.unifesp.br/handle/11600/33491
ISSN: 0219-6352
Other Identifiers: http://dx.doi.org/10.1142/S0219635211002580
Appears in Collections:Em verificação - Geral

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