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Title: Gastroesophageal reflux disease. International evidence-based consensus on the definition of GERD in children and adolescents
Authors: Sherman, P. M.
Hassall, E.
Fagundes-Neto, U. [UNIFESP]
Gold, B. D.
Kato, S.
Koletzko, S.
Orenstein, S.
Rudolph, C.
Vakil, N.
Vandenplas, Y.
Univ Munich
Univ Toronto
Univ British Columbia
Universidade Federal de São Paulo (UNIFESP)
Emory Univ
Tohoku Univ
Univ Pittsburgh
Med Coll Wisconsin
Univ Wisconsin
Marquette Univ
Vrije Univ Brussels
Keywords: Erosive esophagitis
Barrett's mucosa
Issue Date: 1-Feb-2010
Publisher: Springer
Citation: Monatsschrift Kinderheilkunde. New York: Springer, v. 158, n. 2, p. 164-176, 2010.
Abstract: An international consensus on the definition of gastroesophageal reflux disease (GERD) in pediatrics was sought.After a systematic literature search, a set of key statements was developed by an international panel of pediatric gastroenterologists and voted anonymously in a modified Delphi process. the strength of each statement was assessed using the GRADE system.Consensus was reached on 98% of the 59 statements. Consensus items of particular note were: (1) GERD is present when reflux of gastric contents causes troublesome symptoms and/or complications. the definition is restricted in the case of children under similar to 8 years, due to unreliable reporting of incriminating symptoms; (2) the primary role of histology is to exclude other conditions, rather than to establish the diagnosis of GERD; (3) Barrett's esophagus characterizes an esophageal metaplasia that is intestinal metaplasia-positive or -negative; (4) extraesophageal conditions may be associated with GERD, but for most of these conditions causality remains to be established.The consensus statements were developed by means of a rigorous process and can form the basis for clinical trials and practice guidelines.
ISSN: 0026-9298
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