Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/30946
Title: Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain
Authors: Paccola, Carina Cicconi
Gutierrez, Vanessa Pacciari
Longo, Ingrid
Juliano, Luiz [UNIFESP]
Juliano, Maria Aparecida [UNIFESP]
Giorgi, Renata
Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Keywords: Neuropathic pain
S100A9
Antinociception
Sciatic nerve
Chronic constriction injury
Issue Date: 1-Oct-2008
Publisher: Elsevier B.V.
Citation: Peptides. New York: Elsevier B.V., v. 29, n. 10, p. 1806-1814, 2008.
Abstract: The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models. in this study, the effect of mS100A9p was investigated on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in rats. Hyperalgesia, allodynia, and spontaneous pain were assessed to evaluate nociception. These three signs were detected as early as 2 days after sciatic nerve constriction and lasted for over 14 days after CCI. Rats were treated with different doses of mS100A9p by intraplantar, oral, or intrathecal routes on day 14 after CCI, and nociception was evaluated 1 h later. These three routes of administration blocked hyperalgesia, allodynia and spontaneous pain. the duration of the effect of mS100A9p depends on the route used and phenomenon analyzed. Moreover, intraplantar injection of mS100A9p in the contralateral paw inhibited the hyperalgesia on day 14 days after CCI the results obtained herein demonstrate the antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain, suggesting a potential therapeutic use for it in persistent pain syndromes, assuming that tolerance does not develop to mS100A9p. (C) 2008 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/30946
ISSN: 0196-9781
Other Identifiers: http://dx.doi.org/10.1016/j.peptides.2008.05.023
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.