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Title: Variant isolates of human metapneumovirus subgroup B genotype 1 in Campinas, Brazil
Authors: Da Silva, Luciana Helena Antoniassi
Spilki, Fernando Rosado
Riccetto, Adriana Gut Lopes
Almeida, Renata Servan de
Baracat, Emilio Carlos Elias
Arns, Clarice Weis
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: human metapneumovirus
molecular characterization
genotype B subgroup 1
Issue Date: 1-May-2008
Publisher: Elsevier B.V.
Citation: Journal of Clinical Virology. Amsterdam: Elsevier B.V., v. 42, n. 1, p. 78-81, 2008.
Abstract: Background: Human metapneumovirus (HMPV) is a paramyxovirus associated with respiratory illness. the genotypes of HMPV isolates in Brazil have not been well characterized.Objectives: To investigate the presence of HMPV in clinical samples collected from pediatric patients of two university hospitals in the region of Campinas (São Paulo, Brazil) and to genotype them by partial sequencing of the HMPV F gene.Study design: Nasopharyngeal aspirates were collected from children hospitalized between April and September, 2004 because of acute respiratory infections (ARI).Results: We identified HMPV in 8 of 142 (5.6%) clinical samples. We determined through phylogenetic analysis that HMPV isolates in Campinas during the study were clustered within subgroup B genotype 1. Two of the isolates analyzed showed significant differences from previously isolated B I viruses, when compared to HMPV isolated in South Africa and,Canada, and clustered in a separate branch within this genotype.Conclusions: in 2004 in our geographic region all HMPV isolates from pediatric patients were in the B I HMPV genetic group, with two variant isolates. (c) 2007 Elsevier B.V. All rights reserved.
ISSN: 1386-6532
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