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Title: Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents
Authors: Stefani, Helio A.
Oliveira, Carlindo B.
Almeida, Roberta B.
Pereira, Claudio M. P.
Braga, Rodolpho C.
Cella, Rodrigo
Borges, Vanessa C.
Savegnago, Lucielli
Nogueira, Cristina W.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Sergipe (UFS)
Keywords: Biginelli
reactive oxygen species
Issue Date: 1-Apr-2006
Publisher: Elsevier B.V.
Citation: European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 4, p. 513-518, 2006.
Abstract: An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH4Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels. (c) 2006 Elsevier SAS. All rights reserved.
ISSN: 0223-5234
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Appears in Collections:Em verificação - Geral

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