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Title: A xylogalactofucan from the brown seaweed Spatoglossum schroederi stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells
Authors: Rocha, HAD
Bezerra, LCLD
Albuquerque, IRL de
Costa, L. S.
Guerra, CMP
Abreu, L. D. de
Nader, H. B.
Leite, E. L.
Univ Fed Rio Grande Norte
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Apr-2005
Publisher: Georg Thieme Verlag Kg
Citation: Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 71, n. 4, p. 379-381, 2005.
Abstract: The brown seaweed Spatoglossum schroederi (Dictyotaceae) contains three main fucans (fucans A, B and C) with different mobility in electrophoresis. the fucan with highest mobility (fucan C) was precipitated with 2.0 volumes of acetone, purified using a combination of ion exchange chromatography and electrophoresis. It showed an MW of 24 kDa determined by HPLC and Sephadex G-75 chromatography and migrates as a single band in three distinct electrophoretic systems. This fucan contains fucose, xylose, galactose and sulfate in a molar ratio 1 :0.6: 2:2.3. the fucan has neither anticoagulant (from 10 to 100 mu g) nor hemorrhagic activities (100 mu g/mL). in addition, fucan C is neither cytotoxic nor cytostatic. However, fucan C (100 mu g/mL) stimulated the synthesis of an antithrombotic heparan sulfate from endothelial cells of rabbit aorta. the results suggest that fucan C might be used as an antithrombotic therapeutic compound.
ISSN: 0032-0943
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Appears in Collections:Em verificação - Geral

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