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|Title:||A xylogalactofucan from the brown seaweed Spatoglossum schroederi stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells|
Albuquerque, IRL de
Costa, L. S.
Abreu, L. D. de
Nader, H. B.
Leite, E. L.
Univ Fed Rio Grande Norte
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Georg Thieme Verlag Kg|
|Citation:||Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 71, n. 4, p. 379-381, 2005.|
|Abstract:||The brown seaweed Spatoglossum schroederi (Dictyotaceae) contains three main fucans (fucans A, B and C) with different mobility in electrophoresis. the fucan with highest mobility (fucan C) was precipitated with 2.0 volumes of acetone, purified using a combination of ion exchange chromatography and electrophoresis. It showed an MW of 24 kDa determined by HPLC and Sephadex G-75 chromatography and migrates as a single band in three distinct electrophoretic systems. This fucan contains fucose, xylose, galactose and sulfate in a molar ratio 1 :0.6: 2:2.3. the fucan has neither anticoagulant (from 10 to 100 mu g) nor hemorrhagic activities (100 mu g/mL). in addition, fucan C is neither cytotoxic nor cytostatic. However, fucan C (100 mu g/mL) stimulated the synthesis of an antithrombotic heparan sulfate from endothelial cells of rabbit aorta. the results suggest that fucan C might be used as an antithrombotic therapeutic compound.|
|Appears in Collections:||Em verificação - Geral|
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