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Title: World experience of percutaneous ultrasound-guided balloon valvuloplasty in human fetuses with severe aortic valve obstruction
Authors: Kohl, T.
Sharland, G.
Allan, L. D.
Gembruch, U.
Chaoui, R.
Lopes, L. M.
Zielinsky, P.
Huhta, J.
Silverman, N. H.
Univ Munster
Guys & St Thomas Hosp
Columbia Presbyterian Med Ctr
Med Univ Lubeck
Humboldt Univ
Universidade Federal de São Paulo (UNIFESP)
Inst Cardiol Rio Grande do Sul
Tampa Childrens Hosp
Univ Calif San Francisco
Issue Date: 15-May-2000
Publisher: Excerpta Medica Inc
Citation: American Journal of Cardiology. New York: Excerpta Medica Inc, v. 85, n. 10, p. 1230-1233, 2000.
Abstract: Prenatal alleviation of severe fetal aortic valve obstructions by percutaneous ultrasound-guided balloon valvuloplasty has been performed to improve the fate of affected fetuses. the purpose of this study was to analyze the current world experience of these procedures in human fetuses. Data from 72 human fetuses were available for analysis, the mean gestational age at intervention was 29.2 weeks (range 27 to 33), the mean time period between initial presentation and intervention was 3.3 weeks (range 3 days to 9 weeks). Technically successful balloon valvuloplasties were achieved in 7 fetuses, none of whom had an atretic valve. Only 1 of these fetuses remains alive today, of the 5 remaining technical failures, 1 patient with severe aortic stenosis underwent successful postnatal intervention and remains olive. Six patients who survived prenatal intervention died from cardiac dysfunction or at surgery in the first days or weeks after delivery. Four fetuses died early within 24 hours after the procedure, 1 from a bleeding complication, 2 from persistent bradycardias, and 1 at valvotomy after emergency delivery. Thus, the early clinical experience of percutaneous ultrasound-guided fetal balloon valvuloplasty in human fetuses with severe aortic valve obstruction has been poor due to selection of severe cases, technical problems during the procedure, and high postnatal operative mortality in fetuses who survived gestation. Improved patient selection and technical modifications in interventional methods may hold promise to improve outcome in future cases, (C) 2000 by Excerpta Medica, Inc.
ISSN: 0002-9149
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