Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco

Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco

Author Cavalcanti, Ana Maria Salustiano Google Scholar
Brito, Ana Maria de Google Scholar
Salustiano, Daniela Medeiros Google Scholar
Lima, Kledoaldo Oliveira de Google Scholar
Silva, Sirleide Pereira da Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Lacerda, Heloisa Ramos Google Scholar
Institution Laboratório Central de Saúde Pública de Pernambuco Setor de Virologia
Universidade Federal de Pernambuco Programa de Pós-Graduação em Medicina Tropical
Fiocruz Centro de Pesquisa Aggeu Magalhães
Centro de Testagem e Aconselhamento Herbert de Souza
Universidade Federal de São Paulo (UNIFESP)
Abstract Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) were identified among recently diagnosed patients at five sexually transmitted disease/AIDS testing and counselling centres in the metropolitan region of Recife (RMR), Pernambuco, Brazil, between 2007-2009. One-hundred and eight samples were analysed using the Calypte® BED assay. Males predominated (56%), as did patients aged 31-50 years. Twenty-three percent presented evidence of a recent HIV infection. The median CD4+ T lymphocyte count was 408 cells/mm³ and the median viral load was 3.683 copies/mL. The prevalence of primary resistance was 4.6% (confidence interval 95% = 1-8.2%) based on criteria that excluded common polymorphisms in accordance with the surveillance drug resistance mutation criteria. The prevalence of resistance to non-nucleoside reverse transcriptase, nucleoside/nucleotide reverse transcriptase and protease inhibitors were 3.8%, 1.5% and 0.8%, respectively. Fifty-seven percent of strains were from clade B, 37.7% were clade F and 3.1% were clade C; there were no statistically significant differences with respect to resistance between clades. Recent infection tended to be more common in men (p = 0.06) and in municipalities in the south of the RMR (Jaboatão dos Guararapes and Cabo de Santo Agostinho) (p = 0.046). The high prevalence of recent infection and the high prevalence of non-B strains in this poor Brazilian region merit further attention.
Keywords transmitted antiretroviral resistance
HIV subtype
Brazil
recent HIV infection
Language English
Date 2012-06-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 4, p. 450-457, 2012.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 450-457
Origin http://dx.doi.org/10.1590/S0074-02762012000400002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000304853500002
SciELO ID S0074-02762012000400002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7115

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