Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus

Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus

Author Cabral, Rodrigo Sant'Ana Google Scholar
Sartori, Maura Casari Google Scholar
Cordeiro, Inês Google Scholar
Queiroga, Carmen Lucia Google Scholar
Eberlin, Marcos Nogueira Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Moreno, Paulo Roberto Hrihorowitsch Google Scholar
Young, Maria Claudia Marx Google Scholar
Institution Instituto de Botânica de São Paulo Núcleo de Pesquisa em Fisiologia e Bioquímica
Instituto de Botânica de São Paulo Núcleo de Pesquisa Curadoria do Herbário São Paulo
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).
Keywords acetylcholinesterase inhibitors, alkaloids
Conchocarpus fontanesianus
coumarin Rutaceae
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2012-04-01
Published in Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 374-380, 2012.
ISSN 0102-695X (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Farmacognosia
Extent 374-380
Origin http://dx.doi.org/10.1590/S0102-695X2011005000219
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000299742200018
SciELO ID S0102-695X2012000200018 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7037

Show full item record




File

Name: S0102-695X2012000200018.pdf
Size: 2.220Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account