A link between sleep loss, glucose metabolism and adipokines

A link between sleep loss, glucose metabolism and adipokines

Author Padilha, Heloisa Vidigal Guarita Autor UNIFESP Google Scholar
Crispim, Cibele Aparecida Autor UNIFESP Google Scholar
Zimberg, Ioná Zalcman Autor UNIFESP Google Scholar
Souza, Daurea Abadia de Google Scholar
Waterhouse, Jim Maris Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia Faculdade de Medicina
Liverpool John Moores University Research Institute for Sport and Exercise Sciences
Abstract The present review evaluates the role of sleep and its alteration in triggering problems of glucose metabolism and the possible involvement of adipokines in this process. A reduction in the amount of time spent sleeping has become an endemic condition in modern society, and a search of the current literature has found important associations between sleep loss and alterations of nutritional and metabolic contexts. Studies suggest that sleep loss is associated with problems in glucose metabolism and a higher risk for the development of insulin resistance and type 2 diabetes mellitus. The mechanism involved may be associated with the decreased efficacy of regulation of the hypothalamus-pituitary-adrenal axis by negative feedback mechanisms in sleep-deprivation conditions. In addition, changes in the circadian pattern of growth hormone (GH) secretion might also contribute to the alterations in glucose regulation observed during sleep loss. On the other hand, sleep deprivation stress affects adipokines - increasing tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and decreasing leptin and adiponectin -, thus establishing a possible association between sleep-debt, adipokines and glucose metabolism. Thus, a modified release of adipokines resulting from sleep deprivation could lead to a chronic sub-inflammatory state that could play a central role in the development of insulin resistance and type 2 diabetes mellitus. Further studies are necessary to investigate the role of sleep loss in adipokine release and its relationship with glucose metabolism.
Keywords Glucose metabolism
Insulin resistance
Sleep loss
Adipokines
Type 2 diabetes mellitus
Inflammatory status
Language English
Date 2011-10-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 992-999, 2011.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 992-999
Origin http://dx.doi.org/10.1590/S0100-879X2011007500113
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295721600003
SciELO ID S0100-879X2011001000003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6650

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