Autor |
Oliveira, Maria Gabriela Menezes de
![]() ![]() Bueno, Orlando Francisco Amodeo ![]() ![]() Gugliano, Eric Boragan ![]() ![]() |
Instituição | Universidade Federal de São Paulo (UNIFESP) |
Resumo | A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus. |
Assunto |
electroconvulsive shock
memory cued fear conditioning inhibitory avoidance anxiolytic effect analgesic effect |
Idioma | Inglês |
Data | 1998-08-01 |
Publicado em | Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 8, p. 1091-1094, 1998. |
ISSN | 0100-879X (Sherpa/Romeo, fator de impacto) |
Editor | Associação Brasileira de Divulgação Científica |
Extensão | 1091-1094 |
Fonte |
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Direito de acesso | Acesso aberto ![]() |
Tipo | Artigo |
Web of Science | WOS:000075442400009 |
SciELO | S0100-879X1998000800009 (estatísticas na SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/659 |
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