Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

Author Oliveira, Maria Gabriela Menezes de Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Gugliano, Eric Boragan Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.
Keywords electroconvulsive shock
memory
cued fear conditioning
inhibitory avoidance
anxiolytic effect
analgesic effect
Language English
Date 1998-08-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 8, p. 1091-1094, 1998.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1091-1094
Origin http://dx.doi.org/10.1590/S0100-879X1998000800009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000075442400009
SciELO ID S0100-879X1998000800009 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/659

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