Lifetime psychopathology among the offspring of Bipolar I parents

Lifetime psychopathology among the offspring of Bipolar I parents

Author Zappitelli, Marcelo Cardoso Autor UNIFESP Google Scholar
Bordin, Isabel Altenfelder Santos Autor UNIFESP Google Scholar
Hatch, John P. Google Scholar
Caetano, Sheila Cavalcante Autor UNIFESP Google Scholar
Zunta-Soares, Giovana Google Scholar
Olvera, Rene L. Google Scholar
Soares, Jair C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
The University of Texas Health Science Center Departments of Psychiatry and Orthodontics
Universidade de São Paulo (USP)
University of Texas Health Science Center
The University of Texas Health Science Center Department of Psychiatry
Abstract BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.
Keywords Bipolar Disorder
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Krus Endowed Chair in Psychiatry UTHSCSA
Grant number NARSAD: MH 69774
NARSAD: RR 20571
NARSAD: MH068280
Date 2011-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 725-730, 2011.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 725-730
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293122900003
SciELO ID S1807-59322011000500003 (statistics in SciELO)

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