Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon

Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon

Author Fontes, Aparecida Maria Google Scholar
Kashima, Simone Google Scholar
Bonfim-silva, Ricardo Google Scholar
Azevedo, Rochele Google Scholar
Abraham, Kuruvilla Joseph Google Scholar
Albuquerque, Sérgio Roberto Lopes Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Langhi Júnior, Dante Mário Google Scholar
Covas, Dimas Tadeu Google Scholar
Institution Universidade de São Paulo (USP)
Iowa State University Department of Animal Science
Hemocentro do Amazonas
Universidade Federal de São Paulo (UNIFESP)
Santa Casa de São Paulo Faculdade de Ciências Médicas
Abstract Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Keywords Brazilian Amazon population
CR1 haplotypes
Knops blood group polymorphism
malaria
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-01-01
Published in Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 4, p. 539-545, 2011.
ISSN 1415-4757 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Genética
Extent 539-545
Origin http://dx.doi.org/10.1590/S1415-47572011005000051
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000297789600002
SciELO ID S1415-47572011000400002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6170

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