Sporothrix chilensis sp nov (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals

Sporothrix chilensis sp nov (Ascomycota: Ophiostomatales), a soil-borne agent of human sporotrichosis with mild-pathogenic potential to mammals

Author Rodrigues, Anderson Messias Autor UNIFESP Google Scholar
Cruz Choappa, Rodrigo Google Scholar
Fernandes, Geisa Ferreira Autor UNIFESP Google Scholar
De Hoog, G. Sybren Google Scholar
De Camargo, Zoilo Pires Autor UNIFESP Google Scholar
Abstract A combination of phylogeny, evolution, morphologies and ecologies has enabled major advances in understanding the taxonomy of Sporothrix species, including members exhibiting distinct lifestyles such as saprobes, human/animal pathogens, and insect symbionts. Phylogenetic analyses of ITS1/2 + 5.8s sequences split Sporothrix genus in two well-defined groups with dissimilar ecologies. Species embedded in the Sporothrix schenckii complex are frequently agents of human and animal sporotrichosis, and some of these are responsible for large sapronoses and zoonoses around the warmer temperate regions of the world. At the other extreme, basal saprophytic species evolved in association with decaying wood and soil, and are rarely found to cause human disease. We propose to create a new taxa, Sporothrix chilensis sp. nov., to accommodate strains collected from a clinical case of onychomycosis as well as from environmental origins in Chile. Multigene analyses based on ITS1/2 + 5.8s region, beta-tubulin, calmodulin and translation elongation factor 1 alpha revealed that S. chilensis is a member of the Sporothrix pallida complex, and the nearest taxon is Sporothrix mexicana, a rare soil-borne species, non-pathogenic to humans. The ITS region serves as a primary barcode marker, while each one of the protein-coding loci easily recognized species boundaries providing sufficient information for species identification. A disseminated model of murine sporotrichosis revealed a mild-pathogenic potential, with lung invasion. Although S. chilensis is not a primary pathogen, accidental infection may have an impact in the immunosuppressed population. With the introduction of distinct species with similar routes of transmission but different virulence, identification of Sporothrix agents at the species level is mandatory. (C) 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
Keywords Barcoding
Cryptic species
Phylogeny
Taxonomy
Virulence
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Brazilian funding agency Sao Paulo Research Foundation (FAPESP)
Brazilian funding agency National Council for Scientific and Technological Development (CNPq)
Brazilian funding agency Coordination for the Improvement of Higher Education Personnel (CAPES)
Grant number FAPESP: 2009/54024-2
CNPq: 472600/2011-7
Date 2016
Published in Fungal Biology. Oxford, v. 120, n. 2, p. 246-264, 2016.
ISSN 1878-6146 (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 246-264
Origin https://doi.org/10.1016/j.funbio.2015.05.006
Access rights Closed access
Type Article
Web of Science ID WOS:000369551600013
URI https://repositorio.unifesp.br/handle/11600/58627

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