Enteroaggregative Escherichia coli with uropathogenic characteristics are present in feces of diarrheic and healthy children

Enteroaggregative Escherichia coli with uropathogenic characteristics are present in feces of diarrheic and healthy children

Author Nunes, Kamila O. Google Scholar
Santos, Adriana C. P. Google Scholar
Bando, Silvia Y. Google Scholar
Silva, Rosa M. Autor UNIFESP Google Scholar
Gomes, Tania A. T. Autor UNIFESP Google Scholar
Elias, Waldir P. Google Scholar
Abstract Enteroaggregative Escherichia coli (EAEC) has been recently associated with urinary tract infections (UTI). Since EAEC are found in feces of both diarrheic and asymptomatic individuals, their presence in the intestine may be a source of UTI. In this study, we detected in feces of diarrheic and healthy children a subset of EAEC strains with genetic markers of extraintestinal pathogenic E. coli (ExPEC). MLST grouped these EAEC with ExPEC markers in three main clusters along with prototypes strains of EAEC, uropathogenic E. coli and UTI-causing EAEC. Interestingly, the latter cluster was composed by EAEC with ExPEC markers belonging to phylogroup A and closely related to the uropathogenic EAEC O78:H10 strain. Such attributes suggest that these strains have uropathogenic abilities. Therefore, intestinal carriers of these strains are potentially in risk to develop UTIs.
Keywords enteroaggregative E. coli
uropathogenic E. coli
virulence factors
phylogeny
bacterial infections
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
Date 2017
Published in Pathogens And Disease. Oxford, v. 75, n. 8, p. -, 2017.
ISSN 2049-632X (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent -
Origin http://dx.doi.org/10.1093/femspd/ftx106
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000417161300012
URI https://repositorio.unifesp.br/handle/11600/58245

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