Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection

Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection

Author da Silva, Aline A. Google Scholar
Teixeira, Thaise L. Google Scholar
Teixeira, Samuel C. Google Scholar
Machado, Fabricio C. Autor UNIFESP Google Scholar
dos Santos, Marlus A. Google Scholar
Tomiosso, Tatiana C. Google Scholar
Tavares, Paula C. B. Google Scholar
e Silva Brigido, Rebecca T. Google Scholar
Martins, Flavia Alves Google Scholar
de Lira Silva, Nadjania S. Autor UNIFESP Google Scholar
Rodrigues, Cassiano C. Google Scholar
Roque-Barreira, Maria C. Google Scholar
Mortara, Renato A. Autor UNIFESP Google Scholar
Lopes, Daiana S. Google Scholar
Rodrigues Avila, Veridiana de Melo Google Scholar
da Silva, Claudio V. Google Scholar
Abstract Trypanosoma cruzi interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins. Among the glycan-binding proteins is Galectin-3 (Gal-3), which is upregulated after T. cruzi infection. Gal-3 is a member of the lectin family with affinity for beta-galactose containing molecules; it can be found in both the nucleus and the cytoplasm and can be either membrane-associated or secreted. This lectin is involved in several immunoregulatory and parasite infection process. Here, we explored the consequences of Gal-3 deficiency during acute and chronic T. cruzi experimental infection. Our results demonstrated that lack of Gal-3 enhanced in vitro replication of intracellular parasites, increased in vivo systemic parasitaemia, and reduced leukocyte recruitment. Moreover, we observed decreased secretion of pro-inflammatory cytokines in spleen and heart of infected Gal-3 knockout mice. Lack of Gal-3 also led to elevated mast cell recruitment and fibrosis of heart tissue. In conclusion, galectin-3 expression plays a pivotal role in controlling T. cruzi infection, preventing heart damage and fibrosis.
Keywords galectin-3
Trypanosoma cruzi
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Date 2017
Published in Frontiers In Cellular And Infection Microbiology. Lausanne, v. 7, p. -, 2017.
ISSN 2235-2988 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000414310700001

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