Long-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patients

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dc.contributor.author Godoy, Luciana B. M. [UNIFESP]
dc.contributor.author Palombini, Luciana [UNIFESP]
dc.contributor.author Poyares, Dalva [UNIFESP]
dc.contributor.author Dal-Fabbro, Cibele [UNIFESP]
dc.contributor.author Guimaraes, Thais Moura [UNIFESP]
dc.contributor.author Klichouvicz, Priscila Calixto [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Togeiro, Sonia Maria [UNIFESP]
dc.date.accessioned 2020-09-01T13:21:03Z
dc.date.available 2020-09-01T13:21:03Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1093/sleep/zsx175
dc.identifier.citation Sleep. Cary, v. 40, n. 12, p. -, 2017.
dc.identifier.issn 1550-9109
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/58068
dc.description.abstract Objectives: To evaluate the long-term effects of an oral appliance on clinical symptoms, respiratory sleep parameters, sleep quality, and sustained attention in patients with upper airway resistance syndrome (UARS) were compared with placebo. Methods: This study was a randomized placebo-controlled clinical trial. Thirty UARS patients were randomized in two groups: placebo and mandibular advancement device (MAD) groups. UARS criteria were presence of sleepiness (Epworth Sleepiness Scale >= 10) and/or fatigue (Modified Fatigue Impact Scale >= 38) associated with an apnea/hypopnea index <= 5 and a respiratory disturbance index (RDI) > 5 events/hour of sleep, and/or flow limitation in more than 30% of total sleep time. All patients completed the Pittsburgh Sleep Quality Index (PSQI), the Functional Outcomes of Sleep Questionnaire, the Beck Anxiety and Depression Inventories, underwent full-night polysomnography, multiple sleep latency test, and Psychomotor Vigilance Test (PVT). Evaluations were performed before and after 1.5 years of treatment. Results: RDI, number of respiratory effort-related arousal, percentage of total sleep time with flow limitation, and arousal index significantly decreased after 1.5 years of MAD treatment. PSQI total score improved, severity of depression symptoms decreased, and mean reaction time in the PVT, based on the first measurement taken at 8: 00 am, significantly decreased (p=.03) at the end of the protocol. Conclusions: The MAD was effective in decreasing respiratory events in UARS patients. For UARS, 1.5 years of oral appliance therapy also improved sleep quality and sustained attention, and decreased the severity of depression symptoms. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorship CAPES
dc.format.extent -
dc.language.iso eng
dc.publisher Oxford Univ Press Inc
dc.relation.ispartof Sleep
dc.rights Acesso aberto
dc.subject Upper airway resistance syndrome en
dc.subject fatigue en
dc.subject excessive daytime sleepiness en
dc.subject mandibular advancement device en
dc.subject sleep disordered breathing en
dc.subject oral appliance therapy en
dc.title Long-Term Oral Appliance Therapy Improves Daytime Function and Mood in Upper Airway Resistance Syndrome Patients en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Disciplina Med & Biol Sono, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Disciplina Med & Biol Sono, Dept Psicobiol, Sao Paulo, Brazil
dc.identifier.doi 10.1093/sleep/zsx175
dc.description.source Web of Science
dc.identifier.wos WOS:000419000600014
dc.coverage Cary
dc.citation.volume 40
dc.citation.issue 12


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