The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

Author Soares-Silva, Mercedes Google Scholar
Diniz, Flavia F. Google Scholar
Gomes, Gabriela N. Google Scholar
Bahia, Diana Autor UNIFESP Google Scholar
Abstract Leishrnania spp. and Trypanosome cruzi are the causative agents of leishmaniasis and Chagas disease, respectively, two neglected tropical diseases that affect about 25 million people worldwide. These parasites belong to the family Trypanosomatidae, and are both obligate intracellular parasites that manipulate host signaling pathways and the innate immune system to establish infection. Mitogen-activated protein kinases (MAPKs) are serine and threonine protein kinases that are highly conserved in eukaryotes, and are involved in signal transduction pathways that modulate physiological and pathophysiological cell responses. This mini-review highlights existing knowledge concerning the mechanisms that Leishmania spp. and T. cruzi have evolved to target the host's MAPK signaling pathways and highjack the immune response, and, in this manner, promote parasite maintenance in the host.
Keywords MAP kinase
Trypanosoma cruzi
Leishmania
immune evasion of parasites
cellular signaling
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor CNPq fellowship
FAPEMIG fellowship
EAPEMIG
FAPESP
Grant number EAPEMIG: APQ-01674-14
FAPESP: 07/50551-2
Date 2016
Published in Frontiers In Microbiology. Lausanne, v. 7, p. -, 2016.
ISSN 1664-302X (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fmicb.2016.00183
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000370759200001
URI https://repositorio.unifesp.br/handle/11600/57960

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