Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy

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dc.contributor.author Jeronimo, Giovanna [UNIFESP]
dc.contributor.author Nozoe, Karen T. [UNIFESP]
dc.contributor.author Polesel, Daniel N. [UNIFESP]
dc.contributor.author Moreira, Gustavo A. [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.date.accessioned 2020-08-21T17:00:18Z
dc.date.available 2020-08-21T17:00:18Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.nut.2015.09.004
dc.identifier.citation Nutrition. New York, v. 32, n. 3, p. 391-393, 2016.
dc.identifier.issn 0899-9007
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57933
dc.description.abstract Duchenne muscular dystrophy (DMD) is the second most common hereditary genetic disease in humans and has elevated mortality. DMD is an X-linked, life-limiting progressive muscle-wasting disease found predominantly in boys and young men. One of the main treatments for patients with DMD is corticosteroids. However, long-term use may cause major side effects such as obesity, a reduction in vitamin D, and osteoporosis. Sleep-disordered breathing is a common condition among patients with DMD, especially obstructive sleep apnea (OSA). In children, OSA is associated with obesity and a reduction of vitamin D concentration. In this article we aim to explore the interrelationship that exists between corticosteroids, obesity, OSA, and the risk of osteoporosis. Our main hypothesis is that factors such as nutrition and sleep are related to obesity and OSA, respectively. In addition, the chronic use of corticosteroids, obesity, and OSA are factors that can reduce serum levels of vitamin D, triggering osteoporosis. Thus, these factors play a key role in affecting the quality of life for patients with DMD and intervention based on these aspects may improve survival. (C) 2016 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa
dc.description.sponsorship CNPq
dc.format.extent 391-393
dc.language.iso eng
dc.publisher Elsevier Science Inc
dc.relation.ispartof Nutrition
dc.rights Acesso restrito
dc.subject Duchenne muscular dystrophy en
dc.subject Nutrition en
dc.subject Sleep en
dc.subject Quality of life en
dc.title Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.identifier.doi 10.1016/j.nut.2015.09.004
dc.description.source Web of Science
dc.identifier.wos WOS:000370312300015
dc.coverage New York
dc.citation.volume 32
dc.citation.issue 3



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