The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

Author Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Piano Ganen, Aline de Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Santamarina, Aline Boveto Autor UNIFESP Google Scholar
Souza, Gabriel Inacio de Morais Honorato de Autor UNIFESP Google Scholar
Gomes, Aline Dal'Olio Google Scholar
Moreira, Renata Guimaraes Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract The purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there is an association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 postpuberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and Non-MetS (n=76). The interdisciplinary therapy consisted of a 1-year period of nutrition, psychology, physical exercise and clinical support. After therapy, both groups improved metabolic, inflammatory (leptin, adiponectin, leptin/adiponectin ratio, adiponectin/leptin ratio and C-reactive protein) and cardiometabolic profile (PAI-1 and ICAM). Metabolic syndrome prevalence reduced from 28.70% to 12.96%. Both groups reduced myristic acid (C14:0) and increased docosahexaenoic acid (DHA, C22:6n3), heneicosapentaenoic acid (HPA, C21:5n3) and arachidonic acid (C20:4n6). After adjustment for metabolic syndrome and the number of metabolic syndrome parameters, multiple regression analysis showed that changes in VCAM and PAI-1 were negatively associated with changes in cis-linoleic acid (C18:2n6c). Additionally, changes in trans-linoleic acid (C18:2n6t) were also positively associated with these biomarkers. Moreover, leptin and leptin/adiponectin ratio were negatively associated with changes in docosapentaenoic acid (DPA, C22:5n3) and stearidonic acid (SDA, C18:4n3). Adiponectin/leptin ratio was positively associated with docosapentaenoic acid (DPA, C22:5n3). Changes in adiponectin were positively correlated with changes in omega 3, such as heneicosapentaenoic acid (HPA, C21:5n3) and docosapentaenoic acid (DPA, C22:5n3). Results support that interdisciplinary therapy can control inflammatory and cardiometabolic profile in obese adolescents. Moreover, serum fatty acids can be influenced by lifestyle changes and are able to modulate these biomarkers. (C) 2016 Elsevier Inc. All rights reserved.
Keywords Free fatty acids
Inflammation
Cardiometabolic
Interdisciplinary
Metabolic syndrome
Adolescents
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Universidade Federal de São Paulo (UNIFESP)
AFIP
CEPE
CEMSA
Grant number CNPq: 141533/2012-9
CNPq: 300654/2013-8
CAPES: AUX-PE-PNPD 2566/2011
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/041364
Date 2016
Published in Journal Of Nutritional Biochemistry. New York, v. 33, p. 136-144, 2016.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 136-144
Origin https://dx.doi.org/10.1016/j.jnutbio.2016.03.017
Access rights Closed access
Type Article
Web of Science ID WOS:000378011400016
URI https://repositorio.unifesp.br/handle/11600/57702

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