Physical exercise as an epigenetic modulator of brain plasticity and cognition

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dc.contributor.author Fernandes, Jansen [UNIFESP]
dc.contributor.author Arida, Ricardo Mario [UNIFESP]
dc.contributor.author Gomez-Pinilla, Fernando
dc.date.accessioned 2020-08-04T13:40:16Z
dc.date.available 2020-08-04T13:40:16Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1016/j.neubiorev.2017.06.012
dc.identifier.citation Neuroscience And Biobehavioral Reviews. Oxford, v. 80, p. 443-456, 2017.
dc.identifier.issn 0149-7634
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57399
dc.description.abstract A large amount of evidence has demonstrated the power of exercise to support cognitive function, the effects of which can last for considerable time. An emerging line of scientific evidence indicates that the effects of exercise are longer lasting than previously thought up to the point to affect future generations. The action of exercise on epigenetic regulation of gene expression seem central to building an "epigenetic memory" to influence long-term brain function and behavior. In this review article, we discuss new developments in the epigenetic field connecting exercise with changes in cognitive function, including DNA methylation, histone modifications and microRNAs (miRNAs). The understanding of how exercise promotes long-term cognitive effects is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders. en
dc.description.sponsorship National Institute of Health
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.format.extent 443-456
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.relation.ispartof Neuroscience And Biobehavioral Reviews
dc.rights Acesso restrito
dc.subject Exercise en
dc.subject Memory en
dc.subject Epigenetics en
dc.subject Brain en
dc.subject DNA methylation en
dc.subject Histones en
dc.subject miRNAs en
dc.title Physical exercise as an epigenetic modulator of brain plasticity and cognition en
dc.type Artigo
dc.description.affiliation Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA
dc.description.affiliation Univ Calif Los Angeles, Dept Neurosurg, UCLA Brain Injury Res Ctr, Los Angeles, CA 90095 USA
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2013/12692-4
dc.description.sponsorshipID FAPESP: 2013/13725-3
dc.description.sponsorshipID FAPESP: 2015/09234-0
dc.description.sponsorshipID CNPq: 300605/2013-07
dc.identifier.doi 10.1016/j.neubiorev.2017.06.012
dc.description.source Web of Science
dc.identifier.wos WOS:000416879800029
dc.coverage Oxford
dc.citation.volume 80



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