Physical exercise as an epigenetic modulator of brain plasticity and cognition

Physical exercise as an epigenetic modulator of brain plasticity and cognition

Author Fernandes, Jansen Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Gomez-Pinilla, Fernando Google Scholar
Abstract A large amount of evidence has demonstrated the power of exercise to support cognitive function, the effects of which can last for considerable time. An emerging line of scientific evidence indicates that the effects of exercise are longer lasting than previously thought up to the point to affect future generations. The action of exercise on epigenetic regulation of gene expression seem central to building an "epigenetic memory" to influence long-term brain function and behavior. In this review article, we discuss new developments in the epigenetic field connecting exercise with changes in cognitive function, including DNA methylation, histone modifications and microRNAs (miRNAs). The understanding of how exercise promotes long-term cognitive effects is crucial for directing the power of exercise to reduce the burden of neurological and psychiatric disorders.
Keywords Exercise
DNA methylation
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor National Institute of Health
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2013/12692-4
FAPESP: 2013/13725-3
FAPESP: 2015/09234-0
CNPq: 300605/2013-07
Date 2017
Published in Neuroscience And Biobehavioral Reviews. Oxford, v. 80, p. 443-456, 2017.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 443-456
Access rights Closed access
Type Article
Web of Science ID WOS:000416879800029

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