Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

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dc.contributor.author Jamar, Giovana [UNIFESP]
dc.contributor.author de Almeida, Flavio Rossi [UNIFESP]
dc.contributor.author Gagliardi, Antonio [UNIFESP]
dc.contributor.author Sobral, Marianna Ribeiro [UNIFESP]
dc.contributor.author Ping, Chao Tsai [UNIFESP]
dc.contributor.author Sperandio, Evandro [UNIFESP]
dc.contributor.author Romit, Marcelo [UNIFESP]
dc.contributor.author Arantes, Rodolfo [UNIFESP]
dc.contributor.author Dourado, Victor Zuniga [UNIFESP]
dc.date.accessioned 2020-08-04T13:40:15Z
dc.date.available 2020-08-04T13:40:15Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1590/1516-3180.2016.0358280417
dc.identifier.citation Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 5, p. 462-468, 2017.
dc.identifier.issn 1516-3180
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57396
dc.description.abstract BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.format.extent 462-468
dc.language.iso eng
dc.publisher Associacao Paulista Medicina
dc.relation.ispartof Sao Paulo Medical Journal
dc.rights Acesso aberto
dc.subject Anthropometry en
dc.subject Obesity en
dc.subject Diabetes mellitus en
dc.title Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo Unifesp, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, Brazil
dc.description.affiliation Angiocorpore Inst Med Cardiovasc, Dept Cardiovasc Med, Sao Paulo, SP, Brazil
dc.description.affiliation Fed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo Unifesp, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2011/07282-6
dc.identifier.file S1516-31802017000500462.pdf
dc.identifier.scielo S1516-31802017000500462
dc.identifier.doi 10.1590/1516-3180.2016.0358280417
dc.description.source Web of Science
dc.identifier.wos WOS:000417223700008
dc.coverage Sao Paulo
dc.citation.volume 135
dc.citation.issue 5



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