Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

Author Jamar, Giovana Autor UNIFESP Google Scholar
de Almeida, Flavio Rossi Autor UNIFESP Google Scholar
Gagliardi, Antonio Autor UNIFESP Google Scholar
Sobral, Marianna Ribeiro Autor UNIFESP Google Scholar
Ping, Chao Tsai Autor UNIFESP Google Scholar
Sperandio, Evandro Autor UNIFESP Google Scholar
Romit, Marcelo Autor UNIFESP Google Scholar
Arantes, Rodolfo Autor UNIFESP Google Scholar
Dourado, Victor Zuniga Autor UNIFESP Google Scholar
Abstract BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.
Keywords Anthropometry
Obesity
Diabetes mellitus
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Grant number FAPESP: 2011/07282-6
Date 2017
Published in Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 5, p. 462-468, 2017.
ISSN 1516-3180 (Sherpa/Romeo, impact factor)
Publisher Associacao Paulista Medicina
Extent 462-468
Origin http://dx.doi.org/10.1590/1516-3180.2016.0358280417
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000417223700008
SciELO ID S1516-31802017000500462 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57396

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