Periodic limb movement in sleep and sickle cell disease: a neglected association?

Periodic limb movement in sleep and sickle cell disease: a neglected association?

Author Cabanas-Pedro, Ana C. Autor UNIFESP Google Scholar
Roizenblatt, Suely Autor UNIFESP Google Scholar
de Souza, Altay A. L. Autor UNIFESP Google Scholar
Figueiredo, Maria S. Autor UNIFESP Google Scholar
Abstract High frequency of periodic limb movements in sleep (PLMS) has been described among children with sickle cell disease (SCD), but there is little information about PLMS among adults with SCD. We aim to determine the frequency of PLMS among adults with SCD and to identify possible associations with iron status and haemolytic parameters. We analysed polysomnography on 99 adults: 74 with sickle cell anaemia (HbSS), 19 with HbSC (double heterozygosis HbS and HbC) and 6 with HbS-beta thalassaemia. Laboratory data were collected close to the time of the polysomnography examination. The prevalence of PLMS > 5/h was 70% and of PLMS > 15/h 36%, in the total group of patients. No differences were observed regarding gender, use of hydroxyurea and iron parameters. Logistic regression showed an association between PLMS > 15/h and hemolytic parameters: absolute reticulocyte count (p = 0.03) and unconjugated bilirubin (p = 0.01). Our data suggest that PLMS may be associated with manifestations of greater severity in SCD.
Keywords sickle cell disease
periodic limb movement in sleep
disease severity
polysomnography
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor CAPES/SUS (Comissao de Aperfeicoamento de Pessoal do Nivel Superior)
AFIP (Associacao Fundo de Incentivo a Psicofarmacologia)
CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
Date 2017
Published in British Journal Of Haematology. Hoboken, v. 179, n. 1, p. 154-157, 2017.
ISSN 0007-1048 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 154-157
Origin http://dx.doi.org/10.1111/bjh.14811
Access rights Closed access
Type Article
Web of Science ID WOS:000411730000018
URI https://repositorio.unifesp.br/handle/11600/57322

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