Aerobic exercise in polluted urban environments: effects on airway defense mechanisms in young healthy amateur runners

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dc.contributor.author Sá, Matheus Cavalcante de [UNIFESP]
dc.contributor.author Nakagawa, Naomi Kondo
dc.contributor.author Saldiva de Andre, Carmen Diva
dc.contributor.author Carvalho-Oliveira, Regiani
dc.contributor.author Carvalho, Tamas de Santana
dc.contributor.author Nicola, Marina Lazzari
dc.contributor.author de Andre, Paulo Afonso
dc.contributor.author Nascimento Saldiva, Paulo Hilario
dc.contributor.author Vaisberg, Mauro [UNIFESP]
dc.date.accessioned 2020-07-31T12:47:08Z
dc.date.available 2020-07-31T12:47:08Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1088/1752-7163/10/4/046018
dc.identifier.citation Journal Of Breath Research. Bristol, v. 10, n. 4, p. -, 2016.
dc.identifier.issn 1752-7155
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56609
dc.description.abstract In this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of Sao Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy athletes ran for 45 min d(-1) randomly during five consecutive days, with an interval of 48 h before changing environment. Clinical parameters and respiratory tract defense markers were evaluated before and after the first run on Mondays (1 d) and on Fridays (5 d). Street presented higher mean PM2.5 concentrations (65.1 +/- 39.1 mu gm(-3), p < 0.001) and lower temperature (22.0 degrees C, p = 0.010) than Forest (22.6 +/- 15.3 mu g m(-3) and 22.8 degrees C). After 1 d Street running, subjects showed an increment in heart rate (p < 0.001). At day 5, there was twice the number of athletes with impaired nasal mucociliary clearance (MCC) in the Street runners group when compared to the Forest runners group. Exhaled breath condensate pH values increased in the Forest group, with significant differences between groups in day 1 (p = 0.006) and day 5 (p < 0.001), despite the fact that both groups showed values within the normal range. After exposure to both environments, the number of cells in the nasal lavage fluid was reduced after exercise (p = 0.014), without alterations in cell type and IL-8 and IL-10 concentrations. Aerobic exercise can either maintain or acutely enhance MCC and it may help to regulate inflammatory responses in the airways. Here we show that exercise practice in polluted outdoor environment, over a 5 d period, impairs MCC. In contrast, athletes running in the less polluted environment (Forest) show higher exhaled breath condensate pH values when compared to those who exercised in a more polluted environment (Street). en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent -
dc.language.iso eng
dc.publisher Iop Publishing Ltd
dc.relation.ispartof Journal Of Breath Research
dc.rights Acesso restrito
dc.subject air pollution en
dc.subject EBC pH en
dc.subject MCC en
dc.subject cytokines en
dc.subject particulate matter en
dc.subject aerobic exercise en
dc.subject running exercise en
dc.title Aerobic exercise in polluted urban environments: effects on airway defense mechanisms in young healthy amateur runners en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Pathol, Fac Med, LIM 05, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Physiotherapy Commun Sci & Speech Disorders, Fac Med, LIM 34, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Stat, Inst Math & Stat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Department of Otorhinolaryngology and Head and Neck Surgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/51605-9
dc.description.sponsorshipID FAPESP: 13/13598-1
dc.identifier.doi 10.1088/1752-7163/10/4/046018
dc.description.source Web of Science
dc.identifier.wos WOS:000392138100001
dc.coverage Bristol
dc.citation.volume 10
dc.citation.issue 4



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