Actigraphy-Based Sleep Parameters During the Reinstatement of Methamphetamine Self-Administration in Rhesus Monkeys

Actigraphy-Based Sleep Parameters During the Reinstatement of Methamphetamine Self-Administration in Rhesus Monkeys

Author Berro, Laís Fernanda Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Howell, Leonard L. Google Scholar
Abstract The objective of this study was to investigate nighttime activity of nonhuman primates during extinction and cue-and drug-primed reinstatement of methamphetamine self-administration. Adult rhesus monkeys (Macaca mulatta

n = 5) self-administered methamphetamine (0.01 mg/kg/injection, i.v.) under a fixed-ratio 20 schedule of reinforcement. Saline infusions were then substituted for methamphetamine and stimulus light (drug-conditioned stimulus presented during drug self-administration) withheld until subjects reached extinction criteria. Drug-and cue-induced reinstatement effects were evaluated after i.v. noncontingent priming injections of methamphetamine (0.03, 0.1, or 0.3 mg/kg). Activity-based sleep measures were evaluated with Actiwatch monitors a week before (baseline nighttime activity parameters) and throughout the protocol. Although methamphetamine self-administration did not significantly affect nighttime activity compared to baseline, sleeplike parameters were improved during extinction compared to self-administration maintenance. Priming injection of 0.1 mg/kg methamphetamine, but not 0.03 or 0.3 mg/kg, induced significant reinstatement effects. These behavioral responses were accompanied by nighttime outcomes, with increased sleep fragmentation and decreased sleep efficiency in the night following 0.1 mg/kg methamphetamine-induced reinstatement. In the absence of both drug and drug-paired cues (extinction conditions), nighttime activity decreased compared to self-administration maintenance. Additionally, effective reinstatement conditions impaired sleeplike measures. Our data indicate that the reintroduction of the stimulus light as a drug-paired cue increased nighttime activity.
Keywords methamphetamine
nighttime activity
rhesus monkeys
xmlui.dri2xhtml.METS-1.0.item-coverage Washington
Language English
Sponsor U.S. Public Health Service
Associacao Fundo de Incentivo a Pesquisa
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Grant number U.S. Public Health Service: DA10344
U.S. Public Health Service: DA031246
U.S. Public Health Service: ODP51OD11132
Date 2016
Published in Experimental And Clinical Psychopharmacology. Washington, v. 24, n. 2, p. 142-146, 2016.
ISSN 1064-1297 (Sherpa/Romeo, impact factor)
Publisher Amer Psychological Assoc
Extent 142-146
Access rights Closed access
Type Article
Web of Science ID WOS:000372466000007

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