Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism

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dc.contributor.author Conceicao, Rodrigo Rodrigues da [UNIFESP]
dc.contributor.author Laureano-Melo, Roberto
dc.contributor.author Oliveira, Kelen Carneiro [UNIFESP]
dc.contributor.author Melo, Maria Clara de Carvalho [UNIFESP]
dc.contributor.author Kasamatsu, Tereza Sayoko [UNIFESP]
dc.contributor.author Maciel, Rui Monteiro de Barros [UNIFESP]
dc.contributor.author Souza, Janaina Sena de [UNIFESP]
dc.contributor.author Giannocco, Gisele [UNIFESP]
dc.date.accessioned 2020-07-22T13:23:20Z
dc.date.available 2020-07-22T13:23:20Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.physbeh.2016.02.005
dc.identifier.citation Physiology & Behavior. Oxford, v. 157, p. 158-164, 2016.
dc.identifier.issn 0031-9384
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56178
dc.description.abstract Thyroidectomy is a surgical procedure indicated in cases of several maligned or benign thyroid diseases, thus, the aim of our study was to verify how the hypothyroidism induced by thyroidectomy influences behavioral parameters and its relation to thyroid hormones metabolism and neurogenesis at hippocampus. For this purpose, Adult male Wistar rats underwent to thyroidectomy to induce hypothyroidism. Behavioral tests, the thyroid profile and hippocampal gene expression were evaluated in control and in thyroidectomized animals. It was observed that thyroidectomized group had a significant increasing in serum thyroid-stimulating hormone (TSH) and a decreasing in thyroxine (T4) levels as well as in triiodothyronine (T3) serum level. It was also observed reduction of the monocarboxylate transporter 8 (Mct8), thyroid hormone receptor alfa (Tr alpha 1), deiodinase type 2 (Dio2), ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2) and brain-derived neurotrophic factor (Bdnf) mRNA expression in hippocampus of thyroidectomized animals. In the forced swimming test, it was verified that thyroidectomy promotes a decrease in time of immobility and climbing when compared with the control group. In summary, we demonstrated that antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism. This effect could be associated to an impaired neuronal activity in acute stress response as it is observed in forced swimming paradigm. (C) 2016 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)
dc.format.extent 158-164
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.relation.ispartof Physiology & Behavior
dc.rights Acesso restrito
dc.subject Brain en
dc.subject Hypothyroidism induced by thyrodectomy en
dc.subject Depression like behavior en
dc.subject Hippocampus en
dc.title Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Med, Lab Endocrinol Mol & Translac, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Rural Rio de Janeiro, Inst Tecnol, Dept Tecnol Alimentos, Seropedica, RJ, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Med, Lab Endocrinol Mol & Translac, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP, Brazil
dc.identifier.doi 10.1016/j.physbeh.2016.02.005
dc.description.source Web of Science
dc.identifier.wos WOS:000372943000022
dc.coverage Oxford
dc.citation.volume 157



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