Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism

Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism

Author Conceicao, Rodrigo Rodrigues da Autor UNIFESP Google Scholar
Laureano-Melo, Roberto Google Scholar
Oliveira, Kelen Carneiro Autor UNIFESP Google Scholar
Melo, Maria Clara de Carvalho Autor UNIFESP Google Scholar
Kasamatsu, Tereza Sayoko Autor UNIFESP Google Scholar
Maciel, Rui Monteiro de Barros Autor UNIFESP Google Scholar
Souza, Janaina Sena de Autor UNIFESP Google Scholar
Giannocco, Gisele Autor UNIFESP Google Scholar
Abstract Thyroidectomy is a surgical procedure indicated in cases of several maligned or benign thyroid diseases, thus, the aim of our study was to verify how the hypothyroidism induced by thyroidectomy influences behavioral parameters and its relation to thyroid hormones metabolism and neurogenesis at hippocampus. For this purpose, Adult male Wistar rats underwent to thyroidectomy to induce hypothyroidism. Behavioral tests, the thyroid profile and hippocampal gene expression were evaluated in control and in thyroidectomized animals. It was observed that thyroidectomized group had a significant increasing in serum thyroid-stimulating hormone (TSH) and a decreasing in thyroxine (T4) levels as well as in triiodothyronine (T3) serum level. It was also observed reduction of the monocarboxylate transporter 8 (Mct8), thyroid hormone receptor alfa (Tr alpha 1), deiodinase type 2 (Dio2), ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2) and brain-derived neurotrophic factor (Bdnf) mRNA expression in hippocampus of thyroidectomized animals. In the forced swimming test, it was verified that thyroidectomy promotes a decrease in time of immobility and climbing when compared with the control group. In summary, we demonstrated that antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism. This effect could be associated to an impaired neuronal activity in acute stress response as it is observed in forced swimming paradigm. (C) 2016 Elsevier Inc. All rights reserved.
Keywords Brain
Hypothyroidism induced by thyrodectomy
Depression like behavior
Hippocampus
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)
Date 2016
Published in Physiology & Behavior. Oxford, v. 157, p. 158-164, 2016.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 158-164
Origin http://dx.doi.org/10.1016/j.physbeh.2016.02.005
Access rights Closed access
Type Article
Web of Science ID WOS:000372943000022
URI https://repositorio.unifesp.br/handle/11600/56178

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