Is there a role for urinary podocyte excretion assessment in lupus nephritis?

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dc.contributor.author Mansur, Juliana Busato [UNIFESP]
dc.contributor.author Sabino, Amelia Rodrigues Pereira [UNIFESP]
dc.contributor.author Nishida, Sonia Kiyomi [UNIFESP]
dc.contributor.author Kirsztajn, Gianna Mastroianni [UNIFESP]
dc.date.accessioned 2020-07-22T13:23:07Z
dc.date.available 2020-07-22T13:23:07Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.3109/0886022X.2016.1150099
dc.identifier.citation Renal Failure. Abingdon, v. 38, n. 4, p. 643-647, 2016.
dc.identifier.issn 0886-022X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56047
dc.description.abstract Objective To establish the occurrence and intensity of podocyturia and its relation to grade of disease activity, as defined by clinical and laboratory criteria. Methods Prospective, cross-sectional study involving 50 patients with lupus nephritis and 29 controls, which had podocyturia levels determined from random urine samples using an immunofluorescence technique. Disease activity was graded by BILAG (renal criteria) and an additional system used in the service (S2). Results Fifty patients with lupus nephritis (WHO classes III, IV and V), with a median age of 37years, were evaluated. Of these, 86.5% were female, and 52% were BILAG A. Podocyturia quantification in the lupus nephritis and control groups differed significantly (p = 0.009). This score was higher in relation to classes III, IV and V. The correlation with C3 consumption was stronger (p = 0.011) than with C4. The highest levels were found in the most active groups (A and B of BILAG and S2). Lower podocyturia correlated with a lower dose of prednisone. There was no association with the intensity of proteinuria, hematuria or pyuria, serum creatinine levels, among others. Conclusions Podocyturia assessment, which was performed by immunofluorescence in this study, can be used as an indicator of disease activity with the advantage of being a urinary biomarker. The levels proved to be higher in patients with lupus nephritis than in the controls and were particularly higher in class IV. en
dc.description.sponsorship Brazilian Council for Scientific and Technological Development (CNPq)
dc.format.extent 643-647
dc.language.iso eng
dc.publisher Taylor & Francis Ltd
dc.relation.ispartof Renal Failure
dc.rights Acesso aberto
dc.subject Glomerulonephritis en
dc.subject systemic lupus erythematosus en
dc.subject lupus nephritis en
dc.subject podocyturia en
dc.subject podocytes en
dc.subject proteinuria en
dc.title Is there a role for urinary podocyte excretion assessment in lupus nephritis? en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Div Nephrol, Napoleao de Barros St 715, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, UNIFESP, Div Nephrol, Napoleao de Barros St 715, BR-04024002 Sao Paulo, Brazil
dc.identifier.doi 10.3109/0886022X.2016.1150099
dc.description.source Web of Science
dc.identifier.wos WOS:000372164000022
dc.coverage Abingdon
dc.citation.volume 38
dc.citation.issue 4



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