Heart rate recovery improvement in patients following acute myocardial infarction: exercise training, -blocker therapy or both

Heart rate recovery improvement in patients following acute myocardial infarction: exercise training, -blocker therapy or both

Author Medeiros, Wladimir Musetti Autor UNIFESP Google Scholar
Luca, Fabio A. de Google Scholar
Figueredo Junior, Alcides R. de Autor UNIFESP Google Scholar
Mendes, Felipe A. R. Google Scholar
Gun, Carlos Google Scholar
Abstract Heart rate recovery (HRR) is a strong mortality predictor. Exercise training (ET) and -blocker therapy have significant impact on the HRR of patients following myocardial infarction (MI). However, the combination of ET and -blocker therapy, as well as its effectiveness in patients with a more compromised HRR (12bpm), has been under-studied. Male patients (n=64) post-MI were divided: Training+-blocker (n=19), Training (n=15), -blocker (n=11) and Control (n=19). Participants performed an ergometric test before and after 3months of intervention. HRR was obtained during 5min of recovery and corrected by the cardiac reserve (HRRcorrCR). Compared to pre-intervention, HRRcorrCR was significantly increased during the 1st and 2nd minutes of recovery in the Training+-blocker group (70<bold></bold>5% and 37<bold></bold>5%, respectively

P<0<bold></bold>05). A significant improvement, lasting from the 1st to the 4th minute of recovery, was also observed in the Training group (47%, 50%, 25% and 8<bold></bold>7%, respectively

P<0<bold></bold>05). In contrast, the -blocker group showed a reduction in HRRcorrCR during the 2nd and 3rd minutes of recovery (-21<bold></bold>2% and -16<bold></bold>3%, respectively

P<0<bold></bold>05). In addition, interventions involving ET (Training+b, Training) were significantly more effective in patients with a pre-intervention HRR12bpm than for patients with HRR>12bpm. Combination of -blocker therapy with ET does not compromise the effect of training and instead promotes HRR and aerobic capacity improvement. In addition, this combination is particularly beneficial for individuals presenting with a more compromised HRR. However, chronic administration of -blocker therapy alone did not promote improvement in HRR or aerobic capacity.
Keywords autonomic function
beta-blocker
cardiac rehabilitation
exercise testing
exercise training
heart disease
heart rate recovery
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2018
Published in Clinical Physiology And Functional Imaging. Hoboken, v. 38, n. 3, p. 351-359, 2018.
ISSN 1475-0961 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 351-359
Origin http://dx.doi.org/10.1111/cpf.12420
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000430103100002
URI https://repositorio.unifesp.br/handle/11600/55594

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