Evaluation of the isoflavones and estrogen effects on the rat adrenal

Evaluation of the isoflavones and estrogen effects on the rat adrenal

Author Marinho, Darci Souza Autor UNIFESP Google Scholar
Calio, Michele Longoni Autor UNIFESP Google Scholar
Santos, Miriam Aparecida Autor UNIFESP Google Scholar
Ko, Gui Mi Autor UNIFESP Google Scholar
Teixeira, Cristiane Paula Autor UNIFESP Google Scholar
Carbonel, Adriana Ferraz Autor UNIFESP Google Scholar
Lisboa-Nascimento, Telma Autor UNIFESP Google Scholar
Castro, Rodrigo Aquino Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Google Scholar
Antonio Bertoncini, Clelia Rejane Autor UNIFESP Google Scholar
Abstract The aim of this study was to evaluate the morphometry and the gene expression of Ki-67, VEGF and caspase 3 and the stress oxidative in the adrenal gland of ovariectomized rats treated with estrogen or isoflavones. We used 15 Wistar rats ovariectomized treated with isoflavones or estrogen during 30days. At the end of the treatment, the left adrenal gland was removed for subsequent histological studies and the right was used to evaluate gene expression of angiogenesis (VEGF-A), cell proliferation (Ki-67), apoptose (caspase 3 clivated) and oxidative stress. Treatment with estrogen showed a largest increase in the layers of the adrenal cortex than with isoflavones. These hypertrofic effects agree with higher expression elevation of Ki67 and VEGF, which did not occur with the caspase 3, indicating that isoflavones have great proliferative effect on the adrenal gland. Similar results were also observed on superoxide quantification show that isoflavone has a protective effect against oxidative stress. Our results indicate positively the trophic therapeutic potential of isoflavones has a protective effect and can contribute to the development of effective therapies to decrease the symptoms of menopause.
Keywords Adrenal
isoflavone
estrogen
menopause
oxidative stress
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
Grant number CNPq: 130247/2015-4
Date 2017
Published in Gynecological Endocrinology. Abingdon, v. 33, n. 10, p. 811-815, 2017.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 811-815
Origin http://dx.doi.org/10.1080/09513590.2017.1318371
Access rights Closed access
Type Article
Web of Science ID WOS:000413910700014
URI https://repositorio.unifesp.br/handle/11600/55447

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