Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke

Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke

Author Tae, Barbara Google Scholar
Oliveira, Kelen Carneiro Autor UNIFESP Google Scholar
da Conceicao, Rodrigo Rodrigues Autor UNIFESP Google Scholar
Valenti, Vitor Engracia Google Scholar
de Souza, Janaina Sena Autor UNIFESP Google Scholar
Laureano-Melo, Roberto Autor UNIFESP Google Scholar
Sato, Monica Akemi Google Scholar
de Barros Maciel, Rui Monteiro Autor UNIFESP Google Scholar
Giannocco, Gisele Autor UNIFESP Google Scholar
Abstract The side stream cigarette smoke (SSCS) is a contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O-2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions. We aimed to investigate the effects of SSCS exposure on gene and protein expression of Ngb, Cygb, and Mb in different tissue. The Ngb and Cygb gene and protein expression in the cerebral cortex increased after 1 week of rat exposure to SSCS. In hippocampus, the Ngb gene and protein expression increased after 1 week or more of exposure and no change was observed in Cygb gene and protein expression. In myocardium, Mb and Cygb gene expression increased at 1 and 4 weeks of exposure, while protein expression of both increased at 1, 2, 3, and 4 weeks. In lung, observed an increase in Cygb gene and protein expression after 2, 3, and 4 weeks of exposure. The findings suggest that SSCS modulates Ngb, Cygb, and Mb in central and peripheral tissue (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1252-1261, 2017.
Keywords cigarette smoke
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2017
Published in Environmental Toxicology. Hoboken, v. 32, n. 4, p. 1252-1261, 2017.
ISSN 1520-4081 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 1252-1261
Origin http://dx.doi.org/10.1002/tox.22321
Access rights Closed access
Type Article
Web of Science ID WOS:000397534500014
URI https://repositorio.unifesp.br/handle/11600/54863

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