Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Rios, Adiel C. Autor UNIFESP Google Scholar
Salum, Giovanni A. Google Scholar
Pan, Pedro M. Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Levandowski, Mateus L. Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Manfro, Gisele G. Autor UNIFESP Google Scholar
Stertz, Laura Google Scholar
Kauer-Sant'anna, Marcia Google Scholar
Miguel, Euripedes C. Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Replicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents.
Keywords Oxidative stress
Lipid peroxidation
Perinatal complications
Adverse early life environment
Childhood
Psychopathology
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor National Council for Scientific and Technological Development (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Sao Paulo Research Foundation (FAPESP)
Date 2017
Published in European Child & Adolescent Psychiatry. New York, v. 26, n. 5, p. 521-529, 2017.
ISSN 1018-8827 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 521-529
Origin http://dx.doi.org/10.1007/s00787-016-0914-6
Access rights Closed access
Type Article
Web of Science ID WOS:000399701900003
URI https://repositorio.unifesp.br/handle/11600/54611

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