Waist circumference as a predictor of mortality in peritoneal dialysis patients: a follow-up study of 48 months

Waist circumference as a predictor of mortality in peritoneal dialysis patients: a follow-up study of 48 months

Author Castro, Ana Catarina M. Autor UNIFESP Google Scholar
Bazanelli, Ana Paula Autor UNIFESP Google Scholar
Nerbass, Fabiana B. Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Kamimura, Maria A. Autor UNIFESP Google Scholar
Abstract Body-fat gain is a common finding among peritoneal dialysis (PD) patients, and the accumulation of adipose tissue occurs predominantly in the abdominal area. Waist circumference (WC) is a reliable marker of abdominal obesity and its association with worse outcomes has been demonstrated in non-dialysis and haemodialysis patients. We aimed at investigating whether WC measurements as well as the changes over time in WC were able to predict mortality in PD patients. This prospective study included 109 patients undergoing PD (57 % male, age 52 (sd 16) years, 32 % diabetics, 48 % BMI25 kg/m(2)). WC was measured at the umbilicus level (empty abdominal cavity), and values >88 cm for women and >102 cm for men were considered high. Nutritional status and laboratory parameters were also evaluated. WC was measured at baseline and after 6 months, and mortality was registered during a period of 48 months. High WC was observed in 55 % of women and in 23 % of men at baseline. After 6 months, 61 % of the patients showed an increased WC. At the end of the study, twenty-seven deaths were registered. A significant increase in WC was observed only in the non-survivor group. In the Cox regression analysis adjusting for sex, age, duration on dialysis, diabetes, BMI, serum albumin and C-reactive protein, high WC at baseline as well as the 6-month increase in WC were independently associated with mortality. This study demonstrated that a high WC and the increase over time in WC were both predictors of mortality in PD patients.
Keywords Waist circumference
Abdominal obesity
Peritoneal dialysis
Chronic kidney disease
xmlui.dri2xhtml.METS-1.0.item-coverage Cambridge
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
Oswaldo Ramos Foundation
Grant number FAPESP: 06/56124-6
Date 2017
Published in British Journal Of Nutrition. Cambridge, v. 117, n. 9, p. 1299-1303, 2017.
ISSN 0007-1145 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 1299-1303
Origin http://dx.doi.org/10.1017/S0007114517001179
Access rights Closed access
Type Article
Web of Science ID WOS:000404364300010
URI https://repositorio.unifesp.br/handle/11600/54543

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