Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents

Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents

Author Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Vicente, Sofia Emanuelle de Castro Ferreira Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract BACKGROUND: Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance. METHODS: A total of 148 obese adolescents were enrolled in the program. They aged 15-19 y, with Body Mass Index (BMI)>= P95(th) and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (AT) (N.=51) and aerobic plus resistance training (N.=97). Blood samples were collected to analyze adiponectin, glucose and insulin concentrations. The insulin resistance was measured by HOMA-AD and Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR). RESULTS: Both kinds of exercise training promoted a decrease in body mass, body mass index, fat mass, visceral and subcutaneous fat. However, only aerobic plus resistance training was effective to reduce HOMA-AD, insulin and glucose concentration

and increase insulin sensibility and adiponectin concentration. CONCLUSIONS: The aerobic plus resistance training was more effective than AT alone to improve the HOMA-AD, suggesting clinical application on obesity, diabetes, atherosclerosis and metabolic syndrome control in the pediatric population.
Keywords Obesity
Adolescent
Insulin resistance
Exercise
xmlui.dri2xhtml.METS-1.0.item-coverage Turin
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAPESP (CEPID/Sleep)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
CENESP
UNIFESP-EPM
CEPE-GEO Interdisciplinary Obesity Intervention Program
Grant number FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/04136-4
FAPESP: 2013/08522-6
FAPESP: 015/14309-9
FAPESP (CEPID/Sleep): 9814303-3
CAPES AUX-PE-PNPD: 2566/2011
Date 2017
Published in Journal Of Sports Medicine And Physical Fitness. Turin, v. 57, n. 6, p. 831-838, 2017.
ISSN 0022-4707 (Sherpa/Romeo, impact factor)
Publisher Edizioni Minerva Medica
Extent 831-838
Origin https://dx.doi.org/10.23736/S0022-4707.16.06235-6
Access rights Closed access
Type Article
Web of Science ID WOS:000404788300016
URI https://repositorio.unifesp.br/handle/11600/54331

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