Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection

Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection

Author Oliveira, Gabriel Melo De Google Scholar
Masuda, Masako Oya Google Scholar
Rocha, Nazaré N Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Hooper, Cléber S Google Scholar
Araújo-jorge, Tânia C De Google Scholar
Henriques-pons, Andréa Google Scholar
Institution Instituto Oswaldo Cruz-Fiocruz Laboratório de Biologia Celular
Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho
Universidade Federal Fluminense Instituto Biomédico Departamento de Fisiologia e Farmacologia
Universidade Federal de São Paulo (UNIFESP)
Centro de Criação de Animais de Laboratório Departamento de Controle de Qualidade Animal
Abstract Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
Keywords Trypanosoma cruzi
Fas-L
myocarditis
acute kidney injury
Language English
Date 2009-12-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 104, n. 8, p. 1063-1071, 2009.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 1063-1071
Origin http://dx.doi.org/10.1590/S0074-02762009000800002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000274413300002
SciELO ID S0074-02762009000800002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/5401

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