Grape skin extract mitigates tissue degeneration, genotoxicity, and oxidative status in multiple organs of rats exposed to cadmium

Grape skin extract mitigates tissue degeneration, genotoxicity, and oxidative status in multiple organs of rats exposed to cadmium

Author Boiago Gollucke, Andrea P. Autor UNIFESP Google Scholar
Claudio, Samuel R. Autor UNIFESP Google Scholar
Yamamura, Hirochi Autor UNIFESP Google Scholar
Morais, Damila R. Google Scholar
Bataglion, Giovana A. Google Scholar
Eberlin, Marcos N. Google Scholar
Aguiar, Odair, Jr. Autor UNIFESP Google Scholar
Ribeiro, Daniel A. Autor UNIFESP Google Scholar
Abstract The aim of this study was to investigate whether grape skin extract can mitigate the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis for the liver, genotoxicity, and oxidative status in the blood and liver were investigated in this setting. A total of 20 Wistar rats weighing 250g, on average, and 8 weeks of age were distributed into four groups (n=5) as follows: control group (nontreated group)

cadmium group (Cd)

and grape skin extract groups (Cd+GS) at 175 or 350mg/l. Histopathological analysis in liver showed that animals treated with grape skin extract showed improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as indicated by comet and micronucleus assays in animals treated with grape skin extract. Copper-zinc superoxide dismutase and cytochrome c gene expression increased in groups treated with grape skin extract in liver cells. Grape skin extract also reduced the 8-hydroxy-2-deoxyguanosine levels in liver cells compared with the cadmium group. Taken together, our results indicate that grape skin extract can mitigate tissue degeneration, genotoxicity, and oxidative stress induced by cadmium exposure in multiple organs of Wistar rats.
Keywords cadmium
genotoxicity
grape skin extract
oxidative stress
rat
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
CAPES (Coordenacao de Aperfeicoamento de Pessoal de NIvel Superior)
Date 2018
Published in European Journal Of Cancer Prevention. Philadelphia, v. 27, n. 1, p. 70-81, 2018.
ISSN 0959-8278 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 70-81
Origin http://dx.doi.org/10.1097/CEJ.0000000000000273
Access rights Closed access
Type Article
Web of Science ID WOS:000417289000011
URI https://repositorio.unifesp.br/handle/11600/53972

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