Disfunção Endotelial Avaliada Por Dimetilarginina Assimétrica E Desfechos Metabólicos E Renais Em Pacientes Hipertensos

Disfunção Endotelial Avaliada Por Dimetilarginina Assimétrica E Desfechos Metabólicos E Renais Em Pacientes Hipertensos

Author Triches, Cristina Bergmann Autor UNIFESP Google Scholar
Advisor Zanella, Maria Teresa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Graduate program Medicina (Endocrinologia E Metabologia)
Abstract Artigo 1: Asymmetric Dimethylarginine (Adma), Which Is The Main Endogenous Inhibitor Of Nitric Oxide Synthase, Plays A Critical Role In The Process Of Endothelial Dysfunction. We Evaluated The Association Between High Plasma Adma Levels In Hypertensive Patients And The Presence Of Cardiovascular Risk Factors, The Development Of Type 2 Diabetes Mellitus (Dm) And The Development Of Cardiovascular Outcomes, Including Death. We Evaluated 191 Hypertensive Patients Who Were Stratified Into 2 Groups According To The Median Value Of Basal Adma: Those With High Levels Of Plasma Adma (> 0.55 "Mol/L) And Low Levels Of Plasma Adma (" 0.55 "Mol/L) Who Were Prospectively Evaluated Over 5.8 Years. High Adma Levels Were Seen In Patients With Higher Weight, Body Mass Index (Bmi), Waist Circumference, Triglycerides, Uric Acid, And High-Sensitivity C-Reactive Protein (Hs-Crp), And Lower Levels Of Hdl-Col And In Type 2 Diabetic Patients. There Was An Association Between High Plasma Adma Levels And The Occurrence Of Cardiovascula

Nossos Dados Sugerem Que, Em Indivíduos Hipertensos, O Nível Elevado De Adma: " Se Associa À Presença De Fatores De Risco Cardiovascular, Possui Valor Preditivo Positivo Para Morte Cardiovascular E, Em Indivíduos Hipertensos Sem Síndrome Metabólica Ou Dm2, Se Associa Ao Desenvolvimento De Dm2 Ao Longo De 5,8 Anos; " É Um Biomarcador Para Progressão De Doença Renal Crônica, Sendo Um Fator Preditivo Precoce Para O Aparecimento E Progressão De Albuminúria Em Indivíduos Hipertensos Com E Sem Dm2
Keywords Asymmetric Dimethylarginine
Cardiovascular Risk Factors
Diabetes Melitus Type 2
Metabolic Syndrome
Cardiovascular Disease
Cardiovascular Death
Albuminuria
Chronic Kidney Disease
Dimetilarginina Assimétrica
Fatores De Risco Cardiovascular
Diabetes Melitus Tipo 2
Síndrome Metabólica
Doença Cardiovascular
Morte Cardiovascular
Albuminúria
Doença Renal Crônica
Language Portuguese
Date 2018-04-26
Research area Endocrinologia Cardio-Vascular
Knowledge area Ciências Da Saúde
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 212 p.
Origin https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6308191
Access rights Closed access
Type Thesis
URI https://repositorio.unifesp.br/handle/11600/52243

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