Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

Author Monsanto, Rafael da Costa Autor UNIFESP Google Scholar
Schachern, Patricia Google Scholar
Paparella, Michael M. Google Scholar
Cureoglu, Sebahattin Google Scholar
Penido, Norma de Oliveira Autor UNIFESP Google Scholar
Abstract Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM)

control group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groups

significant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages. (C) 2017 Elsevier B.V. All rights reserved.
Keywords Otitis media
Cochlear pathology
Vestibular pathology
Stria vascularis
Cochlear hair cells
Vestibular hair cells
Language English
Sponsor National Institute on Deafness and Other Communication Disorders of the US National Institutes of Health
International Hearing Foundation
Starkey Hearing Foundation
Lions 5M Hearing Foundation
Grant number National Institute on Deafness and Other Communication Disorders of the US National Institutes of Health: U24 DC011968
Date 2017
Published in Hearing Research. Amsterdam, v. 351, p. 2-10, 2017.
ISSN 0378-5955 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 2-10
Origin http://dx.doi.org/10.1016/j.heares.2017.05.003
Access rights Closed access
Type Article
Web of Science ID WOS:000405155500001
URI http://repositorio.unifesp.br/handle/11600/51508

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