Reduced Sympathetic Stimulus and Angiotensin 1-7 Are Related to Diastolic Dysfunction in Spinal Cord-Injured Subjects

Reduced Sympathetic Stimulus and Angiotensin 1-7 Are Related to Diastolic Dysfunction in Spinal Cord-Injured Subjects

Author Schreiber, Roberto Google Scholar
Paim, Layde R. Google Scholar
de Rossi, Guilherme Google Scholar
Matos-Souza, Jose R. Google Scholar
Costa e Silva, Anselmo de A. Google Scholar
Nogueira, Claudio D. Google Scholar
Azevedo, Eliza R. Google Scholar
Alonso, Karina C. Google Scholar
Palomino, Zaira Autor UNIFESP Google Scholar
Sposito, Andrei C. Google Scholar
Casarini, Dulce E. Autor UNIFESP Google Scholar
Gorla, Jose I. Google Scholar
Cliquet, Alberto, Jr. Google Scholar
Nadruz, Wilson, Jr. Google Scholar
Abstract Chronic spinal cord injury (SCI) is often associated with reductions in left ventricular (LV) diastolic function. Impairments in sympathetic activity and activation of the renin-angiotensin system are reported in SCI individuals and may hypothetically be implicated in this association. Hence, the present study verified the relationship between these two neuro-hormonal and cardiac functional and structural characteristics in SCI individuals. Twenty-two men with SCI (injury level above T6 and no voluntary motion below the injury) and 11 able-bodied men were evaluated by clinical, hemodynamic, laboratory, and echocardiographic analysis and had plasmatic renin, angiotensin I (ANGI), angiotensin II (ANGII), angiotensin 1-7 (ANG1-7), and noradrenaline levels measured. SCI subjects had lower noradrenaline (p = 0.003) and higher ANG1-7 (p = 0.009), but similar renin, ANGI, and ANGII levels when compared with able-bodied individuals. In SCI individuals, results of multivariable analysis showed that higher Em, a marker of better LV diastolic function, was directly associated with ANG1-7 (p = 0.05) or ANG1-7/ANGII ratio (p = 0.007), whereas lower noradrenaline levels were independently associated with worse LV diastolic function, as assessed by E/Em ratio (p = 0.028). In conclusion, these results suggest that reduced sympathetic activity and expression of ANG1-7 may be involved in SCI-related diastolic dysfunction.
Keywords angiotensin
diastolic dysfunction
Language English
Sponsor CAPES
CNPq, Brazil]
Grant number FAPESP: 2013/ 07607-8]
CNPq: 304245/2013-5
Date 2017
Published in Journal Of Neurotrauma. New Rochelle, v. 34, n. 15, p. 2323-2328, 2017.
ISSN 0897-7151 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert, Inc
Extent 2323-2328
Access rights Closed access
Type Article
Web of Science ID WOS:000405996900001

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